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Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    is a formidable pathogen and the leading cause of skin and soft tissue infections. We recently showed that the highly conserved\n                    <jats:italic toggle=\"yes\">sasF<\/jats:italic>\n                    gene, encoding for an uncharacterized sortase-anchored surface protein, is up-regulated when\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    colonizes skin. Here, we demonstrate that SasF is an enzyme that has glycoside epimerase activity, which is required for\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    resistance to skin fatty acids. Mutants of\n                    <jats:italic toggle=\"yes\">sasF<\/jats:italic>\n                    are highly impaired in skin colonization and acute infection models. The SasF enzyme is crucial for maintaining the structure of wall teichoic acids and proper\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    surface chemistry. To our knowledge, this is the first report of a bacterial surface epimerase in this pathogen, suggesting that SasF could be a therapeutic target.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aef7070","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:01:42Z","timestamp":1792605702000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["<i>Staphylococcus aureus<\/i>\n                    wall teichoic acid structure dictates virulence potential and resistance to host defenses"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5032-1708","authenticated-orcid":true,"given":"Timothy J.","family":"Enroth","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, 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