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Adv."],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:p>\n                    Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representative meiosis-specific\n                    <jats:italic toggle=\"yes\">DMC1<\/jats:italic>\n                    gene promoter as a bait, we identified two DREAM factors TCX5 and TCX6 required for direct repression of\n                    <jats:italic toggle=\"yes\">DMC1<\/jats:italic>\n                    in somatic cells. Transcriptomic analyses show broad ectopic up-regulation of meiotic genes in\n                    <jats:italic toggle=\"yes\">tcx5\/6<\/jats:italic>\n                    leaves\n                    <jats:italic toggle=\"yes\">.<\/jats:italic>\n                    Consistently,\n                    <jats:italic toggle=\"yes\">tcx5\/6<\/jats:italic>\n                    somatic cells form DSBs and exhibit hypersensitivity to DNA damage compared to wild type. Further genetic analyses reveal that\n                    <jats:italic toggle=\"yes\">SPO11-1<\/jats:italic>\n                    is dispensable for ectopic meiotic gene activation but essential for the DNA damage response in\n                    <jats:italic toggle=\"yes\">tcx5\/6<\/jats:italic>\n                    somatic cells. Last, we demonstrated that TCX5\/6 repress meiotic gene expression through H3K4me3 modification. This finding uncovers an unexpected mechanism for suppressing meiotic recombination in somatic cells, thus preventing genetic diversity and genome instability in organisms.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aef7208","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:58:53Z","timestamp":1792173533000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5\/6 maintains genome stability"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4591-5110","authenticated-orcid":true,"given":"Yuxuan","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7622-3936","authenticated-orcid":true,"given":"Xinwen","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9302-211X","authenticated-orcid":true,"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1647-1072","authenticated-orcid":true,"given":"Cong","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-1892","authenticated-orcid":true,"given":"Chenjiang","family":"You","sequence":"additional","affiliation":[{"name":"Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key 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