{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:41:53Z","timestamp":1792608113977,"version":"4.5.0"},"reference-count":73,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR077761"],"award-info":[{"award-number":["R01AR077761"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE035743"],"award-info":[{"award-number":["R01DE035743"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    The temporomandibular joint (TMJ) is essential for oral functions such as chewing, speaking, and swallowing. Temporomandibular disorders that impair these functions notably reduce patients\u2019 quality of life, and few therapeutic strategies are available to ameliorate these conditions. Here, we identify the neurotrophin receptor (p75\n                    <jats:sup>NTR<\/jats:sup>\n                    ) as a central regulator of mandibular condylar cartilage development, mechanoadaptation, and homeostasis.\n                    <jats:italic toggle=\"yes\">\n                      p75\n                      <jats:sup>NTR<\/jats:sup>\n                    <\/jats:italic>\n                    loss causes condylar and disc hypoplasia, reduced chondrocyte number, impaired load-induced anabolism, and accelerated degeneration. Conditional deletion experiments demonstrate chondrocyte-autonomous requirements for the brain-derived neurotrophic factor (BDNF)\u2013p75\n                    <jats:sup>NTR<\/jats:sup>\n                    axis, which activates phosphoinositide 3-kinase AKT serine\/threonine kinase and p38 mitogen-activated protein kinase signaling to promote proliferation and chondrogenic differentiation while restraining apoptosis. Degenerative human condyles exhibit reduced\n                    <jats:italic toggle=\"yes\">\n                      p75\n                      <jats:sup>NTR<\/jats:sup>\n                    <\/jats:italic>\n                    expression levels. Together, these data establish p75\n                    <jats:sup>NTR<\/jats:sup>\n                    as a molecular hub integrating neurotrophic and mechanical cues to preserve postnatal TMJ architecture and highlight the BDNF-p75\n                    <jats:sup>NTR<\/jats:sup>\n                    axis as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aef7786","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:01:42Z","timestamp":1792605702000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["p75\n                    <sup>NTR<\/sup>\n                    orchestrates chondrogenesis and mechanoadaptation to preserve temporomandibular joint development and homeostasis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4654-0355","authenticated-orcid":true,"given":"Chiho","family":"Kadota-Watanabe","sequence":"first","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."},{"name":"Department of Maxillofacial Orthognathics, Division of Maxillofacial and Neck Reconstruction, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan."},{"name":"Orthopaedic Trauma Institute, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4798-4647","authenticated-orcid":true,"given":"Jinsook","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7549-888X","authenticated-orcid":true,"given":"Eric","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4110-1380","authenticated-orcid":true,"given":"Jey","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, San Francisco, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Won","family":"Chang","sequence":"additional","affiliation":[{"name":"The Shapiro Family Laboratory of Viral Oncology and Aging Research, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-9603","authenticated-orcid":true,"given":"Sowmya","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins University, Baltimore, MD, 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University of California, San Francisco, San Francisco, CA, USA."},{"name":"Department of Orthodontics, School of Dentistry, University of Washington, Seattle, WA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-022-5082-0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"R. 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