{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:20:09Z","timestamp":1787941209838,"version":"build-2784847793"},"reference-count":90,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"35","funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["LC230511"],"award-info":[{"award-number":["LC230511"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["LC230511"],"award-info":[{"award-number":["LC230511"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL124392"],"award-info":[{"award-number":["R01HL124392"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL142596"],"award-info":[{"award-number":["R01HL142596"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL158733"],"award-info":[{"award-number":["R01HL158733"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U2C-CA233238"],"award-info":[{"award-number":["U2C-CA233238"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U2C-CA271898"],"award-info":[{"award-number":["U2C-CA271898"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25PRE1368556"],"award-info":[{"award-number":["25PRE1368556"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002192","name":"LUNGevity Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["DAALA2026"],"award-info":[{"award-number":["DAALA2026"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002192","name":"LUNGevity Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:p>Endothelial dysfunction is recognized to contribute to chronic tissue remodeling in the lung, yet endothelial-derived mechanisms driving these processes remain largely undefined. Here, we show that endothelial inactivation of the LATS1 and LATS2 kinases, key suppressors of the transcriptional regulators YAP and TAZ, elicits distinct responses depending on endothelial identity within different pulmonary vascular beds. Our data indicate that LATS1\/2 inactivation in general capillary endothelial cells induces a reactive capillary injury-like state, whereas a separate endothelial population located within veins adopts a distinct profibrotic state. We show that expansion of this reactive venous endothelial cell population, which is marked by EBF1 and ACKR1 expression, is associated with fibroblast activation, macrophage accumulation, and epithelial remodeling, collectively generating a microenvironment characteristic of fibrotic lung disease. We further demonstrate that pharmacologic inhibition of YAP\/TAZ-TEAD signaling prevents stromal and immune remodeling and fibrotic lesion formation following endothelial LATS1\/2 inactivation. These findings identify LATS1\/2-mediated restraint of YAP\/TAZ as essential for lung endothelial homeostasis and highlight a distinct venous cell response as a direct contributor to fibrotic lung remodeling.<\/jats:p>","DOI":"10.1126\/sciadv.aef8468","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:58:31Z","timestamp":1787939911000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["LATS1\/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9593-505X","authenticated-orcid":true,"given":"Konstantinos","family":"Kontodimas","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Pulmonary Center, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4936-1459","authenticated-orcid":true,"given":"Ahmed A.","family":"Raslan","sequence":"additional","affiliation":[{"name":"Pulmonary Center, Boston University, Boston, MA, USA."},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Arthritis and Autoimmune Diseases Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6032-3335","authenticated-orcid":true,"given":"Benjamin","family":"Spira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7131-3377","authenticated-orcid":true,"given":"Crystal","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Pulmonary Center, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0198-4035","authenticated-orcid":true,"given":"Janardhan","family":"Karapurkar","sequence":"additional","affiliation":[{"name":"Pulmonary Center, Boston University, Boston, MA, USA."},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Arthritis and Autoimmune Diseases Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8628-8343","authenticated-orcid":true,"given":"Yohana","family":"Kefella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0183-6139","authenticated-orcid":true,"given":"Darren","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Bioinformatics Program, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8560-7017","authenticated-orcid":true,"given":"Xintao","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Arthritis and Autoimmune Diseases Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6699-2132","authenticated-orcid":true,"given":"Jennifer E.","family":"Beane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Bioinformatics Program, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3375-8665","authenticated-orcid":true,"given":"Giovanni","family":"Ligresti","sequence":"additional","affiliation":[{"name":"Pulmonary Center, Boston University, Boston, MA, USA."},{"name":"Department of Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Arthritis and Autoimmune Diseases Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-4541","authenticated-orcid":true,"given":"Xaralabos","family":"Varelas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA."},{"name":"Pulmonary Center, Boston University, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00770-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.01.009"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2822-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.052318"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022724-105226"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00236.2025"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.182880"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00517-4"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.158079"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49545-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0431TR"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abm5755"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49477-6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38177-2"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62431-4"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00486-7"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705751"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2024-0046OC"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adl5473"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125635"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31890-4"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85092"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125014"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0070-z"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00300.2014"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.04.026"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaz4028"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mju046"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.06.003"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.322258"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.11.002"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00584-y"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00178.2025"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102376"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.87"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77483"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.113639"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102798"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1199010"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.016"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00573-2"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.03.019"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146243"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.163105"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00508-x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"crossref","unstructured":"S. Kotla J. Lee K. A. Ko W. Chen V. S. K. Samanthapudi O. Hoang G. F. Mejia S. Li K. L. Schadler L. A. Rivera M. Imanishi K. C. T. Samperio J. H. Kim K. C. Ostos-Mendoza K. N. Mariscal-Reyes A. Deswal J. P. Cooke K. Fujiwara N. L. Palaskas E. Koutroumpakis Y. J. Gi R. Pathania C. Morrell P. L. Lorenzi L. Tan I. Madhmud N. M. J. Hanssen L. Yvan-Charvet E. N. Chini J. Herrmann H. G. Vasquez Y. H. Shen J. F. Martin H. Xu E. H. Seeley J. K. Burks P. S. Brookes G. Wang N. T. Le J. I. Abe Downregulation of LATS1\/2 drives endothelial senescence-associated stemness (SAS) and atherothrombotic lesion formation. bioRxiv 2025.06.19.660635 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.06.19.660635.","DOI":"10.1101\/2025.06.19.660635"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1983"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102551"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1972"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01045-4"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934105"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4162"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.10.5035"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2024.12.002"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21865-2"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00139.2017"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.11.007"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15647-5"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/039463200601900303"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202012-4418LE"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2300182"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02441-2018"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85530"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.020"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-0542-8"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0717"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-025-00370-3"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007822"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014783"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012494"},{"key":"e_1_3_2_74_2","doi-asserted-by":"crossref","unstructured":"W. Tian T. T.-H. Wu S. Gu J. L. Chang C. Huang R. Vinh A. M. Andruska K. K. Song D. Kim Y. Zhu S. Lee J. Pan P. N. Kao T. Desai L. S. Prince L. D. Butcher X. Jiang M. Rabinovitch K. Red-Horse M. R. Nicolls An embryonic artery-forming niche reactivates in pulmonary arterial hypertension. bioRxiv 2025.05.02.651303 [Preprint] (2025). https:\/\/doi.org\/10.1101\/2025.05.02.651303.","DOI":"10.1101\/2025.05.02.651303"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0292OC"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-021-02015-7"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18243"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.02.003"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.187328.112"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.70102"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.99"},{"key":"e_1_3_2_82_2","doi-asserted-by":"crossref","unstructured":"A. P. Earhart R. A. Alburquerque M. Starick A. Nallapu L. Garnica A. N. Ozanturk R. K. Maurya X. Wu J. A. Haspel H. S. Kulkarni The C3-C3aR axis modulates trained immunity in alveolar macrophages. bioRxiv 2024.11.01.621042 [Preprint] (2024). https:\/\/doi.org\/10.1101\/2024.11.01.621042.","DOI":"10.1101\/2024.11.01.621042"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500044"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.173374"},{"key":"e_1_3_2_85_2","first-page":"57037","article-title":"An optimized Evans blue protocol to assess vascular leak in the mouse","volume":"12","author":"Wick M. J.","year":"2018","unstructured":"M. J. Wick, J. W. Harral, Z. L. Loomis, E. C. Dempsey, An optimized Evans blue protocol to assess vascular leak in the mouse. J. Vis. Exp. 12, 57037 (2018).","journal-title":"J. Vis. Exp."},{"key":"e_1_3_2_86_2","unstructured":"Y. Wang I. Sarfraz R. Hong Y. Koga S. Alabdullatif N. Pervaiz D. Jenkins V. Akavoor X. Cao S. Bandyadka A. Leshchyk T. Faits M. Khan Z. Wang W. Johnson M. Liu J. Campbell singleCellTK: Comprehensive and Interactive Analysis of Single Cell RNA-Seq Data (Bioconductor 2025)."},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-1950-6"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40173-5"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2022-0165OC"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01819-2"}],"container-title":["Science Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/sciadv.aef8468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:00:10Z","timestamp":1787940010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aef8468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":90,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2026,8,28]]}},"alternative-id":["10.1126\/sciadv.aef8468"],"URL":"https:\/\/doi.org\/10.1126\/sciadv.aef8468","relation":{},"ISSN":["2375-2548"],"issn-type":[{"value":"2375-2548","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"eaef8468"}}