{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:11:19Z","timestamp":1788977479068,"version":"build-2803163510"},"reference-count":61,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"37","funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-NRFF14-2022-0003"],"award-info":[{"award-number":["NRF-NRFF14-2022-0003"]}],"id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2628-M-A49-008"],"award-info":[{"award-number":["NSTC 113-2628-M-A49-008"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","award":["U2102d2002"],"award-info":[{"award-number":["U2102d2002"]}],"id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marsden Fund Council","award":["21-UOA-237"],"award-info":[{"award-number":["21-UOA-237"]}]},{"name":"Catalyst: Seeding General Grant","award":["24-UOA-048-CSG"],"award-info":[{"award-number":["24-UOA-048-CSG"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,11]]},"abstract":"<jats:p>\n                    Catalyst design principles for generating multicarbon (C\n                    <jats:sub>2+<\/jats:sub>\n                    ) products from electrochemical carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ) reduction (CO\n                    <jats:sub>2<\/jats:sub>\n                    R) and carbon monoxide (CO) reduction (COR) are often similar and used interchangeably. However, here we demonstrate how a copper bismuth (CuBi) catalyst generates a drastically different product output for CO\n                    <jats:sub>2<\/jats:sub>\n                    R versus COR, offering a valuable case study. During CO\n                    <jats:sub>2<\/jats:sub>\n                    R, we observe predominant formate production, due to selective adsorption of the CO\n                    <jats:sub>2<\/jats:sub>\n                    reactant onto Bi sites rather than Cu sites. On the other hand, acetate is observed as the primary product for COR because formate production on Bi sites is shut down. Specifically, with the optimal CuBi catalyst, we achieve a high acetate Faradaic efficiency of 68.2% at 100 milliamperes per square centimeter under COR conditions. Experiments involving the coreduction of\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    \/\n                    <jats:sup>12<\/jats:sup>\n                    CO feeds of varying mixing ratios show that acetate has the highest carbon-12 content among the products. This suggests that CO-selective sites (Cu\n                    <jats:sub>CO<\/jats:sub>\n                    ) could play a role in facilitating selective acetate production. Notably, analysis of the acetate isotopologues also reveals a preference for the formation of\n                    <jats:sup>12<\/jats:sup>\n                    CH\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>13<\/jats:sup>\n                    COO\n                    <jats:sup>\u2212<\/jats:sup>\n                    over\n                    <jats:sup>13<\/jats:sup>\n                    CH\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>12<\/jats:sup>\n                    COO\n                    <jats:sup>\u2212<\/jats:sup>\n                    . We propose this to be due to an acetate-selective pathway involving asymmetric hydrogenation of *\n                    <jats:sup>12<\/jats:sup>\n                    CO\n                    <jats:sup>13<\/jats:sup>\n                    CO to *\n                    <jats:sup>12<\/jats:sup>\n                    CH\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>13<\/jats:sup>\n                    CO (ketene). This pathway is promoted at high pH and is postulated to occur at the interfaces between Cu\n                    <jats:sub>CO<\/jats:sub>\n                    and CO\n                    <jats:sub>2<\/jats:sub>\n                    -selective sites (Cu\n                    <jats:sub>CO2<\/jats:sub>\n                    ). Together, our results provide mechanistic insights into acetate formation under COR conditions.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aef9216","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:58:47Z","timestamp":1788976727000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A bimetallic CuBi catalyst for enhanced electrochemical CO reduction to acetate"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9235-9121","authenticated-orcid":true,"given":"Ruoou","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4122-0301","authenticated-orcid":true,"given":"Chengyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences, The University of Auckland, Auckland 1010, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9015-6397","authenticated-orcid":true,"given":"Jiguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6648-6203","authenticated-orcid":true,"given":"Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5417-7801","authenticated-orcid":true,"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-9771","authenticated-orcid":true,"given":"Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117580, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Analysis and Test Center Guangdong University of Technology, Guangdong University of Technology, Guangzhou 510006, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-2723","authenticated-orcid":true,"given":"Sung-Fu","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry and Center for Emergent Functional Matter Science, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7322-0129","authenticated-orcid":true,"given":"Ziyu","family":"Mi","sequence":"additional","affiliation":[{"name":"Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research, Singapore 627833, 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