{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:25:13Z","timestamp":1789154713443,"version":"build-2803163510"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"34","funder":[{"name":"NIH\/NCI","award":["CA009560"],"award-info":[{"award-number":["CA009560"]}]},{"name":"NIH\/NIEHS","award":["UH3 ES029073"],"award-info":[{"award-number":["UH3 ES029073"]}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["R01HD114195"],"award-info":[{"award-number":["R01HD114195"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Endometriosis Foundation"},{"name":"Friends of Prentice Foundation"}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:p>Endometriosis is a chronic, hormone-dependent disease characterized by altered endometrial stromal function, but mechanistic and translational studies have been hindered by the lack of tractable human models. Here, we establish an induced pluripotent stem cell (iPSC)\u2013based platform derived from patients with endometriosis to model endometrial stromal differentiation in a controlled human context. Using a defined differentiation protocol, endometriosis-derived iPSCs transition from pluripotency through mesenchymal commitment toward stromal-like states and acquire transcriptional hormone responsiveness. Transcriptomic analyses reveal coordinated repression of pluripotency and proliferative programs with induction of stromal lineage signatures. Comparison with independent transcriptomic datasets demonstrated that in vitro\u2013derived stromal cells progressively acquired gene expression profiles resembling eutopic endometrial stromal programs in endometriosis. Conditioned media from iPSC-derived stromal cells also induced transcriptional reprogramming in THP-1 macrophage-like cells. Together, these findings establish a patient-derived platform for investigating stromal differentiation and stromal-immune interactions in endometriosis.<\/jats:p>","DOI":"10.1126\/sciadv.aeg2362","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:59:26Z","timestamp":1787162366000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Endometriosis-derived iPSCs reveal conserved stromal maturation and endocrine responsiveness"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-0753","authenticated-orcid":true,"given":"Hannah","family":"McDowell","sequence":"first","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Sun","sequence":"additional","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-8683","authenticated-orcid":true,"given":"Ross","family":"McNally","sequence":"additional","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-3609","authenticated-orcid":true,"given":"Cassandra","family":"Huerta","sequence":"additional","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5101-0565","authenticated-orcid":true,"given":"Huma","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Pittsburgh School of Medicine (UPSOM), Pittsburgh, PA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-6667","authenticated-orcid":true,"given":"Angel","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stem Cell Core, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sule","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Division of Reproductive Science in Medicine, Northwestern University, Chicago, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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