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Lurie Comprehensive Cancer Center","doi-asserted-by":"publisher","award":["Translational Engineering Initiative"],"award-info":[{"award-number":["Translational Engineering Initiative"]}],"id":[{"id":"10.13039\/100011249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["IITP-RS-2025-02214780"],"award-info":[{"award-number":["IITP-RS-2025-02214780"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,7,17]]},"abstract":"<jats:p>Evaluating soft tissue elasticity provides critical biomechanical insights essential for the precise characterization of various physiological and pathological conditions. Here, we present the clinical validation of a wireless, compact wearable system designed for direct, location-specific monitoring of the elastic modulus of the skin and underlying tissues via vibro-rotational biomechanical dynamics. Validated by computational models and experiments, the device uses a tunable skin interface to enable depth-controlled measurements across diverse anatomical sites. Two human subject studies, one involving patients with cancer-related lymphedema and the other involving patients with systemic scleroderma, yield data that correlate with standard clinical metrics. This technology offers the potential for longitudinal assessments in these and other contexts, in both clinical and home settings.<\/jats:p>","DOI":"10.1126\/sciadv.aeg2631","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:03:21Z","timestamp":1784138601000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["A wearable biomechanical system for medical evaluation of soft tissue disorders"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4486-7725","authenticated-orcid":true,"given":"Min-Seung","family":"Jo","sequence":"first","affiliation":[{"name":"Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-756X","authenticated-orcid":true,"given":"Hee-Sup","family":"Shin","sequence":"additional","affiliation":[{"name":"School of Science and Engineering, University of Missouri Kansas City, Kansas City, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-1931","authenticated-orcid":true,"given":"Jin-Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-9369","authenticated-orcid":true,"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-8024","authenticated-orcid":true,"given":"Sonwoo","family":"Jung","sequence":"additional","affiliation":[{"name":"Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul, Republic of Korea."},{"name":"School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3453-6834","authenticated-orcid":true,"given":"Jungyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1137-5273","authenticated-orcid":true,"given":"Tae Wan","family":"Park","sequence":"additional","affiliation":[{"name":"Querrey-Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8328-5587","authenticated-orcid":true,"given":"Jodi L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Robert H. 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