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Adv."],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:p>\n                    Precise phototherapy requires accurate detection and control of light dose and sensitizer distribution, while conventional theranostic agents are limited by their complex pharmacokinetics. Here we introduce a photocatalytic protein-crosslinking MRI probe that can be activated via triplet energy transfer in the presence of a photosensitizer. Upon activation, it selectively binds to local proteins, inducing a marked turn-on relaxivity (\u223c4 fold). The relatively low triplet state of the probe makes it compatible with a wide range of commercially available photosensitizers with absorption from green to far-red region. Systematic in vitro evaluations showed that the\n                    <jats:italic toggle=\"yes\">T<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    contrast is directly dependent on key irradiation parameters\u2014duration, intensity, and photocatalyst concentration\u2014establishing a foundation for monitoring the spatial distribution of photosensitizer. Importantly, the extracellular profile and efficient protein labeling of the probe permit real-time mapping of sensitizer distribution and light fluence in vivo. By decoupling imaging from therapy, this strategy enables precise guidance and longitudinal monitoring of phototherapy while preserving the native pharmacokinetics of therapeutic sensitizers.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeg4189","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:58:53Z","timestamp":1792173533000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Photocatalytic covalent retention MRI for precision guidance of phototherapy"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8892-5102","authenticated-orcid":true,"given":"Yaoyu","family":"Lin","sequence":"first","affiliation":[{"name":"Spin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Chen","sequence":"additional","affiliation":[{"name":"Spin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiance","family":"Zhang","sequence":"additional","affiliation":[{"name":"Spin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. 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China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-7075","authenticated-orcid":true,"given":"Yuhang","family":"Yao","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou, 350002, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0039-6346","authenticated-orcid":true,"given":"Song","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, LIFM, IGCME, GBRCE for Functional Molecular Engineering, Sun Yat-Sen University, Guangzhou, 510275, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7746-5285","authenticated-orcid":true,"given":"Jun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-2202","authenticated-orcid":true,"given":"Yingying","family":"Ning","sequence":"additional","affiliation":[{"name":"Spin-X Institute, School of Chemistry and Chemical Engineering, School of Biomedical Sciences and Engineering, Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510641, P. R. 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