{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:40:37Z","timestamp":1792608037153,"version":"4.5.0"},"reference-count":67,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["T2425006"],"award-info":[{"award-number":["T2425006"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Engineering Fund of Fudan University","award":["YG2025-KEY-03"],"award-info":[{"award-number":["YG2025-KEY-03"]}]},{"name":"The Program of Shanghai Academic Research Leaders","award":["23XD1420200"],"award-info":[{"award-number":["23XD1420200"]}]},{"name":"Shanghai Science and Technology Innovation Action Project","award":["24CL2901100"],"award-info":[{"award-number":["24CL2901100"]}]},{"name":"Shanghai Academy of Natural Sciences"},{"name":"Shanghai Institute for Mathematics and Interdisciplinary Sciences","award":["SIMIS-ID-2025-NC"],"award-info":[{"award-number":["SIMIS-ID-2025-NC"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    Transition metal carbides and nitrides (MXenes) are emerging as transformative materials for bioelectronics. However, the advancement of MXene-based field-effect transistor (FET) biosensors is hindered by the lack of high-quality aqueous-stable materials and the low signal transduction efficiency intrinsic to their metallic nature. To address these issues, we report an ultrasensitive biosensing platform enabled by an in-situ fluorination strategy of MXene. By substituting unstable oxygen-containing terminations with chemically stable fluorine terminations in a mild reaction, we synthesized high-quality fluorinated MXene with the record-breaking ambipolar field-effect mobility (\u03bc\n                    <jats:sub>p<\/jats:sub>\n                    \u00a0=\u00a010.42 cm\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0V\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    , \u03bc\n                    <jats:sub>n<\/jats:sub>\n                    \u00a0=\u00a030.23 cm\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0V\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). The highly electronegative fluorinated interface suppresses interfacial electrical double-layer capacitance, boosting signal transduction efficiency. Consequently, the platform achieves the lowest limit of detection (LOD) of 0.26 fg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    antigen MPT64 among MXene FETs up to date, accompanied by a high current response of 35.02% at LOD. Clinical validation across 126 serum samples demonstrated a diagnostic accuracy of 97.6% with a detection time of 38 s, exhibiting the high-performance and reliable biosensing in complex physiological environments.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeg5289","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:01:42Z","timestamp":1792605702000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["High ambipolar mobility fluorinated MXene for ultrasensitive biosensing transistors"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1588-4959","authenticated-orcid":true,"given":"Yang","family":"Yue","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Materials and Devices, Fudan University, Shanghai 200433, China."},{"name":"Department of Materials Science, Fudan University, Shanghai, 200433, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4325-6546","authenticated-orcid":true,"given":"Junhong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Materials and Devices, Fudan University, Shanghai 200433, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China."},{"name":"Department of Macromolecular Science, Fudan University, Shanghai, 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-0460","authenticated-orcid":true,"given":"Xuejun","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Materials and Devices, Fudan University, Shanghai 200433, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China."},{"name":"Department of Macromolecular Science, Fudan University, Shanghai, 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Tang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Materials and Devices, Fudan University, Shanghai 200433, China."},{"name":"State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, China."},{"name":"Department of Macromolecular Science, Fudan University, Shanghai, 200433, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-2316","authenticated-orcid":true,"given":"Yunqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Materials and Devices, Fudan University, Shanghai 200433, China."},{"name":"Department of Materials Science, Fudan University, Shanghai, 200433, 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