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Adv."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>\n                    Menkes disease, caused by\n                    <jats:italic toggle=\"yes\">ATP7A<\/jats:italic>\n                    mutations, leads to severe copper deficiency and fatal neurodegeneration. Current copper-histidine therapy fails to restore brain function. Copper nanoclusters (CuNCs) were designed for their ultrasmall size to cross physiological barriers and deliver copper directly to the whole organism, including the brain. In\n                    <jats:italic toggle=\"yes\">Mo-blo<\/jats:italic>\n                    mice (ATP7A deficient), daily subcutaneous CuNCs markedly improved survival, normalized cuproprotein activities, and restored cognitive and motor functions. Unlike other treatments, CuNCs effectively penetrate the blood-brain barrier, deliver copper to cuproproteins, offering unprecedented neurological rescue. This breakthrough could transform Menkes disease treatment, providing a first-ever therapy for brain copper deficiency. Further clinical development may unlock lifesaving solutions for this rare, fatal disorder.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeg6972","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:26Z","timestamp":1790791106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Restoring brain functions in the Mo-blo mouse model of Menkes disease with copper nanoclusters"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8452-2488","authenticated-orcid":true,"given":"Audrey","family":"Malard\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lorraine, Inserm, NGERE, F-54000 Nancy, 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