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Adv."],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:p>\n                    Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    gene expression to reconstruct a whole-brain glymphatic-related topography and link it to vascular physiology, glioma, and vulnerability to neurodegenerative diseases. We find that\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    expression is highly organized across the brain, peaking in subcortical, ventral, and periventricular territories, consistent with a clearance axis near cerebrospinal fluid reservoirs and perivascular interfaces. Linking\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    expression to vascular organization,\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    -enriched regions show lower normative blood perfusion, but lie close to areas commonly affected by cerebral small vessel disease. Turning to neurodegeneration, we find that atrophy patterns colocalize with\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    expression, most strongly for tau and TDP-43 proteinopathies, and high-atrophy regions lie close to\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    hotspots in anatomical and structural connectome space. Normative positron emission tomography markers of neuroinflammation strengthen the spatial alignment between\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    expression and disease atrophy. Last, we show that glioma is most frequent in\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    -enriched regions. Collectively, this work highlights how\n                    <jats:italic toggle=\"yes\">AQP4<\/jats:italic>\n                    expression relates to brain physiology and vulnerability.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeg8117","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:59:49Z","timestamp":1790186389000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Spatial organization of AQP4 water channel expression in the human brain"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6447-6417","authenticated-orcid":true,"given":"Tahmineh","family":"Taheri","sequence":"first","affiliation":[{"name":"Montr\u00e9al Neurological Institute, McGill University, Montr\u00e9al, Qu\u00e9bec, 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