{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:13:21Z","timestamp":1791612801137,"version":"4.3.4"},"reference-count":39,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"31","funder":[{"DOI":"10.13039\/501100023996","name":"Singapore Food Agency","doi-asserted-by":"publisher","award":["NRF-SFSRND2SIH-0001"],"award-info":[{"award-number":["NRF-SFSRND2SIH-0001"]}],"id":[{"id":"10.13039\/501100023996","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Research Foundation Competitive Research Programme","award":["NRF-CRP22-2019-0001"],"award-info":[{"award-number":["NRF-CRP22-2019-0001"]}]},{"name":"Temasek Life Sciences Laboratory and National University of Singapore","award":["Intramural research support"],"award-info":[{"award-number":["Intramural research support"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>\n                    Poly(A)-binding proteins (PABPs) are canonically recognized for their roles in mRNA-dependent processes through binding to the poly(A) tail of mRNA. However, whether PABPs possess functions distinct from their action on mRNA, particularly in controlling major developmental transitions, has remained unexplored. Here, we uncover a hitherto unknown role for two PABPs, PAB2 and PAB8, in flowering time control in\n                    <jats:italic toggle=\"yes\">Arabidopsis thaliana<\/jats:italic>\n                    . We demonstrate that PAB2 and PAB8 interact with RNA-binding protein 45C (RBP45C) and determine its cytoplasmic retention. This prevents nuclear entry of RBP45C and its function in promoting the transcription and splicing of the key floral repressor\n                    <jats:italic toggle=\"yes\">FLOWERING LOCUS C<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">FLC<\/jats:italic>\n                    ). Furthermore, low ambient temperature attenuates the interaction between PAB2 and RBP45C, resulting in late flowering attributable to compromised cytoplasmic retention of RBP45C and elevated\n                    <jats:italic toggle=\"yes\">FLC<\/jats:italic>\n                    expression. Our findings identify a non-canonical role of PABPs as a cytoplasmic anchor for RBP45C, which serves as a thermosensory switch of\n                    <jats:italic toggle=\"yes\">FLC<\/jats:italic>\n                    expression to fine-tune flowering in response to cool ambient temperature.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeg8264","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:58:34Z","timestamp":1785520714000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["Poly(A)-binding proteins act as a thermosensory switch to control flowering via cytoplasmic retention of RNA-binding protein 45C"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4223-5708","authenticated-orcid":true,"given":"An","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2477-2884","authenticated-orcid":true,"given":"Songyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5303-8967","authenticated-orcid":true,"given":"Jiahui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore."},{"name":"Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Engineering, Ningbo University, Ningbo, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-8855","authenticated-orcid":true,"given":"Hao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Singapore."},{"name":"Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604, 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