{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:46:47Z","timestamp":1791089207278,"version":"4.1.0"},"reference-count":45,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"26","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571148"],"award-info":[{"award-number":["82571148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62474078"],"award-info":[{"award-number":["62474078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2025YFC3510300"],"award-info":[{"award-number":["2025YFC3510300"]}]},{"name":"The Fundamental Research Funds for the Central Universities of China"},{"name":"Interdisciplinary Innovation Team Project of Norman Bethune Health Science Department Jilin University","award":["2025JBGS04"],"award-info":[{"award-number":["2025JBGS04"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,6,26]]},"abstract":"<jats:p>Intelligent wearable theranostic systems are advancing personalized health care by enabling continuous monitoring and proactive therapy. However, managing chronic oral diseases such as caries and periodontitis is challenging due to the oral cavity\u2019s complex, spatially heterogeneous microenvironments and limited space for powered intraoral electronics. To address this, we developed a wireless, battery-free, and wearable intelligent therapeutic aligner (WiB-ITA) that integrates a butterfly-inspired dual-sided flexible integrated theranostic electrode array (iTEA) to simultaneously monitor compartment-matched pH and nitrite and electrochemically gate on-demand antimicrobial release. The system is powered and commanded via a relay-assisted near-field communication (NFC)\u2013Bluetooth low energy (BLE) dual-hop link, enabling stable battery-free operation across tooth positions and full-arch usability. Validated from in vitro to preliminary human studies, WiB-ITA establishes a scalable, compartment-matched intraoral closed-loop theranostic framework. This integrated theranostic platform represents a breakthrough in personalized oral health care and provides a paradigm for managing other chronic conditions.<\/jats:p>","DOI":"10.1126\/sciadv.aeg9950","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T18:00:04Z","timestamp":1782324004000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":3,"title":["A battery-free wireless intelligent aligner for spatially resolved, closed-loop theranostics of chronic oral diseases"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1719-2287","authenticated-orcid":true,"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Jilin Provincial Key Laboratory of Oral and Craniofacial Diseases and Tissue Reconstruction, School and Hospital of Stomatology, Jilin University, Changchun 130021, 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