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Hamster infection with transgenic cercariae, the infectious stage of this parasitic platyhelminth, recovered from miracidial infection of snails, or from sporocysts generated in vitro from transgenic miracidia and implantation in snails, produced EGFP-positive adult worms. Sequencing of the edited GSH1 and analyses of filial generations demonstrated chromosomal integration and the stable transformation of\n                    <jats:italic toggle=\"yes\">S. mansoni<\/jats:italic>\n                    . 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