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Carter Research Fund"},{"name":"NIH-NICHD Intellectual and Developmental Disabilities Research Center","award":["P50 HD103573"],"award-info":[{"award-number":["P50 HD103573"]}]},{"name":"UNC Office for Undergraduate Research","award":["Summer Undergraduate Research Fellowship"],"award-info":[{"award-number":["Summer Undergraduate Research Fellowship"]}]},{"name":"UNC School of Medicine","award":["Core Facilities Pilot Project Award"],"award-info":[{"award-number":["Core Facilities Pilot Project Award"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    Interferon-\u03bb (IFN-\u03bb, type III IFN) mediates antiviral immunity at anatomic barriers, including the maternal-fetal interface. To investigate the effects of IFN-\u03bb during congenital Zika virus (ZIKV) infection, we infected mice lacking the IFN-\u03b1\u03b2 receptor (\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) or both the IFN-\u03b1\u03b2 and IFN-\u03bb receptors (\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic toggle=\"yes\">Ifnlr1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) at embryonic day 9 and found that loss of maternal IFN-\u03bb signaling resulted in greater transplacental transmission, highlighting a protective effect of IFN-\u03bb at the maternal-fetal interface. To investigate the spatial relationship between ZIKV infection and antiviral responses, we used HiPlex RNAscope on the entire gravid uterus and found that IFN-\u03bb was expressed more proximal to the site of ZIKV infection in\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    dams compared to\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic toggle=\"yes\">Ifnlr1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    dams. We performed immunophenotyping of the placenta and uterus by flow cytometry and found a decrease in dendritic cells and natural killer (NK) cells in the uterus of\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic toggle=\"yes\">Ifnlr1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    dams compared to\n                    <jats:italic toggle=\"yes\">Ifnar1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    dams, but NK cell depletion did not affect fetal infection. Using conditional knockout mice, we identified maternal dendritic cells as the key IFN-\u03bb\u2013responsive cell type mediating protection against ZIKV congenital infection. Together, our data support a model in which IFN-\u03bb signaling to maternal dendritic cells increases dendritic cell accumulation in the uterus, which facilitates a protective antiviral response that restricts ZIKV congenital infection.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeh1073","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:58:42Z","timestamp":1792778322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Interferon-\u03bb signaling to maternal dendritic cells protects against congenital Zika virus infection"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-116X","authenticated-orcid":true,"given":"Margaret R.","family":"Dedloff","sequence":"first","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Reinhardt","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-0557","authenticated-orcid":true,"given":"Tessa-Jonne F.","family":"Ropp","sequence":"additional","affiliation":[{"name":"Neuroscience Microscopy Core Facility, Carolina Institute for Developmental Disabilities &amp; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-6740","authenticated-orcid":true,"given":"Joel","family":"Rivera-Cardona","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-7676","authenticated-orcid":true,"given":"Celeste R.","family":"Robles","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-6947","authenticated-orcid":true,"given":"Rebecca L.","family":"Casazza","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-4685","authenticated-orcid":true,"given":"J. 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