{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:33:00Z","timestamp":1785526380824,"version":"3.56.0"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"31","funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1292.19.077"],"award-info":[{"award-number":["1292.19.077"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>\n                    Circadian rhythms regulate diverse immune processes, yet how they influence memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell differentiation remains unclear. Here, we show that the time of day of antigen encounter shapes CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell fate and antiviral immunity. Immunization during the active phase promotes the generation of progenitor-like memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and enhances T cell-mediated protection upon viral challenge. Mechanistically, dendritic cell-intrinsic circadian clocks regulate expression of the costimulatory ligand CD70, thereby directing T cell differentiation. These findings uncover a dendritic cell-mediated circadian mechanism that governs memory T cell fate decisions and suggest that aligning immune priming with circadian time may be leveraged to optimize T cell immunity.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeh3719","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:58:34Z","timestamp":1785520714000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Dendritic cell circadian clocks shape memory CD8\n                    <sup>+<\/sup>\n                    T cell differentiation"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1264-3559","authenticated-orcid":true,"given":"Ward","family":"Vleeshouwers","sequence":"first","affiliation":[{"name":"Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-5832","authenticated-orcid":true,"given":"Suzanne","family":"van Duikeren","sequence":"additional","affiliation":[{"name":"Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0249-2948","authenticated-orcid":true,"given":"J. Fr\u00e9derique","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2761-1015","authenticated-orcid":true,"given":"Dominique M. B.","family":"Veerkamp","sequence":"additional","affiliation":[{"name":"Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5077-8405","authenticated-orcid":true,"given":"Marissa E.","family":"Linger","sequence":"additional","affiliation":[{"name":"Leiden University Center for Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sytze H. 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