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Adv."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>\n                    Implantable wireless ultrasound microdevices for intratumoral therapy are hindered by inadequate miniaturization for deep-seated sites and toxic lead-based piezoelectrics. Here, we report an injectable, lead-free, submillimeter therapeutic dust (TheraDust; 1.0 millimeters by 1.0 millimeters by 0.9 millimeters) for ultrasound-driven wireless chemo-photodynamic combined therapy. The core of the device is a lead-free tin-doped barium titanate piezoelectric ceramic that features a multiphase coexistence at physiological temperature and exhibits a high piezoelectric coefficient (\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    <jats:sub>33<\/jats:sub>\n                    \u00a0=\u00a0460 picocoulombs per newton). The TheraDust integrates with an ultrasound-responsive drug-loaded hydrogel for precise intratumoral injection. Under programmable ultrasound, it generates light for photodynamic therapy and triggers on-demand chemotherapeutic release for enhanced treatment. In animal models of breast cancer, the device achieved potent tumor suppression, reducing the final tumor volume to less than 3% after five treatment sessions (5 minutes each) and could be retrieved minimally invasively posttreatment. This platform can be adapted to deliver a range of therapeutic stimuli wirelessly, offering a versatile strategy for treating deep-seated pathologies.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeh5237","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:26Z","timestamp":1790791106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Intratumoral therapeutic dust for chemo-photodynamic combination treatment"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2076-4488","authenticated-orcid":true,"given":"Rui","family":"Lin","sequence":"first","affiliation":[{"name":"School of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, 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China, Chengdu 611731, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6483-8034","authenticated-orcid":true,"given":"Kui","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials and Environmental Engineering, Chengdu Technological University, Chengdu 611730, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Electronic Thin Films and Integrated Devices, National Engineering Center of Electromagnetic Radiation Control Materials, University of Electronic Science and Technology of China, Chengdu 611731, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3815-2029","authenticated-orcid":true,"given":"Zhihe","family":"Long","sequence":"additional","affiliation":[{"name":"School of Physics, University of Electronic Science and Technology of China, Chengdu, 611731, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Han","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengyi","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Breast, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0048-7583","authenticated-orcid":true,"given":"Zhuoxuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast, Sichuan 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