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Adv."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:p>\n                    Impaired insulin secretion represents a key feature of type 2 diabetes (T2D), a major global health burden. Insulin release from pancreatic \u03b2 cells is regulated by G protein\u2013coupled receptors linked to different functional classes of G proteins. The potential metabolic role of \u03b2 cell G\n                    <jats:sub>12\/13<\/jats:sub>\n                    (G\n                    <jats:sub>12<\/jats:sub>\n                    hereafter) signaling remains unexplored. Thus, we studied the potential metabolic outcomes of \u03b2 cell G\n                    <jats:sub>12<\/jats:sub>\n                    activation by using a combination of mouse gene knockout technology and \u03b2 cell\u2013specific chemogenetic approaches. We found that selective activation of \u03b2 cell G\n                    <jats:sub>12<\/jats:sub>\n                    signaling strongly promoted insulin secretion, thus protecting mice against obesity-associated metabolic deficits and improving glycemic control in a mouse model of T2D. Mechanistic studies with perifused pancreatic mouse islets identified ROCK as a key downstream effector of G\n                    <jats:sub>12<\/jats:sub>\n                    signaling and potent trigger of insulin secretion. Collectively, these findings suggest that G protein\u2013coupled receptors linked to G\n                    <jats:sub>12<\/jats:sub>\n                    in \u03b2 cells represent potential targets for antidiabetic drugs.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeh5504","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:59:39Z","timestamp":1787767179000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Activation of G\n                    <sub>12<\/sub>\n                    -type G proteins in pancreatic \u03b2 cells protects against impaired glucose homeostasis"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-1320","authenticated-orcid":true,"given":"Srinivas","family":"Pittala","sequence":"first","affiliation":[{"name":"Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and 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