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Adv."],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:p>\n                    Second near-infrared (NIR-II; 1000 to 1700 nanometers) aggregation-induced emission luminogens (AIEgens) hold great promise for imaging-guided precision tumor phototherapy yet are limited by the intrinsic trade-off between fluorescence brightness and photothermal performance. Existing design strategies often yield complex molecular structures while inadequately addressing this trade-off. Herein, we propose a \u201cMinor Tweaks, Major Leaps\u201d concept: Simple modification of the star NIR-II AIEgen\n                    <jats:bold>\n                      2TT-\n                      <jats:italic toggle=\"yes\">o<\/jats:italic>\n                      C6B\n                    <\/jats:bold>\n                    (less than 5% change in molecular weight) markedly improves both NIR-II fluorescence brightness and photothermal performance. The thus-obtained new NIR-II AIEgen,\n                    <jats:bold>ST-CZ<\/jats:bold>\n                    , ranks among leading phototheranostic agents, exhibiting a long emission maximum at 1082 nanometers, a high fluorescence quantum yield of 4.3%, and a great photothermal conversion efficiency of 69% in nanoparticles. Leveraging these superior properties,\n                    <jats:bold>ST-CZ<\/jats:bold>\n                    enables cerebrovascular imaging with an advanced resolution of 19.0 micrometers, and the derived multifunctional platform achieves tumor progression\u2013associated vascular remodeling visualization and efficient metastatic tumor ablation via synergistic photothermal immunotherapy. This work provides a robust strategy for developing high-performance NIR-II AIEgens for advanced biomedical applications.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aeh5939","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:58:26Z","timestamp":1790791106000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A NIR-II AIEgen with superior fluorescence and photothermal performance for precision theranostics"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0191-0965","authenticated-orcid":true,"given":"Huanlong","family":"Zheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors of Jilin Province, College of Electronic Science and Engineering, College of Integrated Circuits, Jilin University, Changchun 130012, 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