{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:51:44Z","timestamp":1792007504953,"version":"4.4.0"},"reference-count":56,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"38","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372172"],"award-info":[{"award-number":["32372172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31761143007"],"award-info":[{"award-number":["31761143007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072121"],"award-info":[{"award-number":["32072121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2023YFF1000404"],"award-info":[{"award-number":["2023YFF1000404"]}]},{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops of China","award":["Horti-3Y-2024-013"],"award-info":[{"award-number":["Horti-3Y-2024-013"]}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,9,18]]},"abstract":"\n Potato late blight caused by\n Phytophthora infestans<\/jats:italic>\n threatens global food security. Unlike the fact that most race-specific resistance to\n P. infestans<\/jats:italic>\n (\n Rpi<\/jats:italic>\n ) genes is rapidly overcome by evolving pathogen populations, the\n R8<\/jats:italic>\n gene from\n Solanum demissum<\/jats:italic>\n has conferred durable, quantitative resistance for nearly a century despite encoding a canonical coiled-coil\u2013type nucleotide-binding, leucine-rich repeat (NLR) protein. We identified specific\n R8<\/jats:italic>\n gene analogs that act as negative modulators of\n R8<\/jats:italic>\n -mediated immunity. These\n R8<\/jats:italic>\n gene analogs lack independent resistance functions but perturb the recognition of avirulence effector Avr8 by R8 and interfere with oligomerization and plasma membrane association of NRC2, a helper NLR essential for the R8 signaling pathway. Stable overexpression of such RGAs effectively compromises\n R8<\/jats:italic>\n -mediated resistance in both potato and\n Nicotiana benthamiana<\/jats:italic>\n . We propose that this endogenous regulation balances the intensity of\n R8<\/jats:italic>\n -mediated immunity, likely reducing selection pressure on the pathogen population and prolonging resistance durability. Our findings reveal a regulatory layer where genetically linked RGAs control resistance (R) protein\u2013mediated immunity, providing a conceptual framework for durable resistance breeding.\n <\/jats:p>","DOI":"10.1126\/sciadv.aeh7029","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:02:56Z","timestamp":1789581776000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":1,"title":["A built-in brake for plant immunity: Resistance (R) protein\u2013mediated immunity is fine-tuned by\n R<\/i>\n gene analogs"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0660-9815","authenticated-orcid":true,"given":"Jiahui","family":"Nie","sequence":"first","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Hubei Hongshan Laboratory (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetong","family":"Qi","sequence":"additional","affiliation":[{"name":"Xianghu Laboratory, Hangzhou 311231, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4318-4746","authenticated-orcid":true,"given":"Zeng","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3808-6176","authenticated-orcid":true,"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuo","family":"Fan","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University (HZAU), Wuhan 430070, China."},{"name":"Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Wuhan 430070, China."},{"name":"Potato Engineering and Technology Research Center of Hubei Province (HZAU), Wuhan 430070, 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