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Adv."],"published-print":{"date-parts":[[2026,9,4]]},"abstract":"<jats:p>\n                    Pancreatic ductal adenocarcinoma (PDAC) is unresponsive to standard immunotherapies despite harboring cancer neoantigens capable of eliciting T cell responses. We completed two phase 1 clinical trials (NCT03956056 and NCT03122106) evaluating safety and immunogenicity of synthetic long peptide (SLP) and DNA personalized cancer vaccines (PCVs). PCVs were administered after resection and adjuvant chemotherapy. Tumor\/normal whole-exome sequencing, RNA sequencing, and pVACtools were used to identify and prioritize candidate PCV neoantigens. PCVs were well tolerated without any grade\u00a0\u22653 adverse events. Neoantigen-specific responses were demonstrated by interferon-\u03b3 enzyme-linked immunospot and intracellular cytokine staining. Expanded T cell receptor clonotypes were sequenced and transduced into autologous peripheral blood mononuclear cells to confirm neoantigen specificity. When compared with a contemporaneous institutional propensity-matched cohort, PCV patients demonstrated a trend toward prolonged median overall survival (4.4 versus 3.5 years, log-rank\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u00a0=\u00a00.23). Overall, PDAC PCVs are safe and feasible and elicit polyclonal T cell responses, linking prioritized cancer neoantigens to functional antitumor immunity.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aei1190","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:58:46Z","timestamp":1788544726000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Synthetic long peptide and DNA personalized cancer vaccines induce robust neoantigen-specific T cell responses in pancreatic cancer"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0057-5870","authenticated-orcid":true,"given":"Felicia","family":"Zhang Perkins","sequence":"first","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2464-5403","authenticated-orcid":true,"given":"Xiuli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Yeung Lawrence","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-5126","authenticated-orcid":true,"given":"Yilin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Cullinan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-7950","authenticated-orcid":true,"given":"Kartik","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-8981","authenticated-orcid":true,"given":"Carlos A.","family":"Parra-Lopez","sequence":"additional","affiliation":[{"name":"Universidad Nacional de Colombia Medical School, Department of Microbiology, Bogot\u00e1, Colombia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-6700","authenticated-orcid":true,"given":"Christopher A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA."},{"name":"The Alvin J. 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