{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T18:39:43Z","timestamp":1792780783514,"version":"4.5.0"},"reference-count":52,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"43","funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["NIH R35GM153387"],"award-info":[{"award-number":["NIH R35GM153387"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,23]]},"abstract":"<jats:p>\n                    Arginine methylation regulates diverse cellular processes, yet how methyl-arginine reader proteins couple this modification to kinase signaling in vivo remains poorly defined. Here, we identify staphylococcal nuclease and Tudor domain containing 1 (SND1) as a pancreas-enriched effector that links symmetric dimethylarginine (SDMA) recognition to S6 kinase 2 (S6K2) activation. Disruption of SDMA-mediated binding by a point mutation in the SND1 Tudor domain markedly diminishes ribosomal protein S6 (S6) phosphorylation in the pancreas. Mechanistically, SND1 engages SDMA-modified arginines within the carboxyl-terminal glycine-arginine\u2013rich (GAR) motif of S6K2 and promotes S6K2-dependent S6 phosphorylation. Mice harboring lysine substitutions at these GAR arginines (\n                    <jats:italic toggle=\"yes\">S6k2<\/jats:italic>\n                    RK) phenocopy Snd1 Tudor-mutant (\n                    <jats:italic toggle=\"yes\">Snd1<\/jats:italic>\n                    knock-in) animals, exhibiting impaired pancreatic S6 phosphorylation. Transcriptomic analyses reveal extensive overlap in dysregulated pathways between\n                    <jats:italic toggle=\"yes\">Snd1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">S6k2<\/jats:italic>\n                    mutant pancreata, supporting a shared signaling cascade. Together, these findings establish a methylation-dependent reader-kinase axis that links protein arginine methyltransferase 5\u2013catalyzed arginine methylation to tissue-specific control of ribosome signaling and cellular stress adaptation.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aei1547","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:58:42Z","timestamp":1792778322000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A methylation-dependent reader couples arginine methylation to S6K2 signaling in vivo"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-9101","authenticated-orcid":true,"given":"Yalong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9113-9694","authenticated-orcid":true,"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjie","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-6069","authenticated-orcid":true,"given":"Daniel J.","family":"McGrail","sequence":"additional","affiliation":[{"name":"Center for Immunotherapy and Precision Immuno-Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8654-461X","authenticated-orcid":true,"given":"Han","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8899-1050","authenticated-orcid":true,"given":"Mark T.","family":"Bedford","sequence":"additional","affiliation":[{"name":"Department of Epigenetics &amp; Molecular Carcinogenesis, The University of Texas MD Anderson 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