{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:47:36Z","timestamp":1792003656385,"version":"4.4.0"},"reference-count":48,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"42","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22379083"],"award-info":[{"award-number":["22379083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22532002"],"award-info":[{"award-number":["22532002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020359","name":"State Key Laboratory of Advanced Displays and Optoelectronics Technologies, Hong Kong University of Science and Technology","doi-asserted-by":"publisher","award":["SKL-ChE-25T04"],"award-info":[{"award-number":["SKL-ChE-25T04"]}],"id":[{"id":"10.13039\/501100020359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.science.org"],"crossmark-restriction":true},"short-container-title":["Sci. Adv."],"published-print":{"date-parts":[[2026,10,16]]},"abstract":"<jats:p>\n                    The selective oxidation of methane under mild conditions remains a formidable challenge because of the inert C\u2500H bond and the ease of over-oxidation. Here we report a facile strategy that enables methane conversion at room temperature and ambient pressure using molecular O\n                    <jats:sub>2<\/jats:sub>\n                    and commercially available Cu powder in dilute aqueous H\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>4<\/jats:sub>\n                    . The reaction is capable of proceeding with only trace CO\n                    <jats:sub>2<\/jats:sub>\n                    formation, producing methyl bisulfate and methanol as the primary partial oxidation products. In situ Raman spectroscopy indicates that an in situ O\n                    <jats:sub>2<\/jats:sub>\n                    -derived Cu\n                    <jats:sub>2<\/jats:sub>\n                    O surface is the reaction-relevant phase associated with C\u2500H bond activation. The observed selectivity arises from bisulfate adsorption on this Cu\n                    <jats:sub>2<\/jats:sub>\n                    O surface, which suppresses methanol over-oxidation, together with the interception of surface-generated methyl intermediates to form oxidation-resistant methyl bisulfate. This Cu\/O\n                    <jats:sub>2<\/jats:sub>\n                    -H\n                    <jats:sub>2<\/jats:sub>\n                    SO\n                    <jats:sub>4<\/jats:sub>\n                    system demonstrates that methane can be selectively oxidized under mild aqueous conditions and provides mechanistic insight into Cu\/O\n                    <jats:sub>2<\/jats:sub>\n                    -mediated oxidation, suggesting a bisulfate-assisted approach to suppressing over-oxidation that may be applicable to other substrates.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aei3285","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:59:24Z","timestamp":1792000764000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["Bisulfate-mediated selective methane oxidation under mild aqueous conditions"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6069-5489","authenticated-orcid":true,"given":"Shike","family":"Lu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China."},{"name":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Chun","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0583-0793","authenticated-orcid":true,"given":"Wenxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-0485","authenticated-orcid":true,"given":"Mu-Jeng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-257X","authenticated-orcid":true,"given":"Bingjun","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China."},{"name":"Ordos Laboratory, Inner Mongolia 017000, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-2629","authenticated-orcid":true,"given":"Qi","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Engineering and Low-Carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China."},{"name":"Ordos Laboratory, Inner Mongolia 017000, 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