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Adv."],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:p>\n                    Natural products (NPs) serve as both inspirations and resources for the discovery of bioactive compounds. However, their application in green agrochemical discovery faces limitations such as low activity, short duration of efficacy, potential toxicity and residue issues from structural modifications, and constraints in exploring chemical and biological space. Here, we propose the concept and design principles of pro-natural products (PrNPs), which effectively address these limitations and open a broad avenue for bioactive compound discovery. PrNPs are functional compounds designed to degrade into NPs under application conditions. Using this strategy, we designed and synthesized a structurally diverse ester-based PrNP collection with 170 members by combining natural acids and alcohols and found a promising green fungicide candidate, PrNP\n                    <jats:bold>6E<\/jats:bold>\n                    , with excellent control efficacy against major plant diseases such as rapeseed\n                    <jats:italic toggle=\"yes\">Sclerotinia<\/jats:italic>\n                    stem rot, rice sheath blight, and apple\n                    <jats:italic toggle=\"yes\">Valsa<\/jats:italic>\n                    canker. Cheminformatic analysis, antifungal activity, degradation behavior, and safety assessment reveal that\n                    <jats:bold>6E<\/jats:bold>\n                    combines the advantageous properties of both NPs and agrochemicals and exhibits suitable duration of efficacy, controllable degradation into NPs after fulfilling its function, broad safety, and environmental compatibility. The PrNP strategy shows great potential in enhancing the efficiency of finding green agrochemicals with novel chemotypes and mechanisms of action and in promoting sustainable development of agriculture.\n                  <\/jats:p>","DOI":"10.1126\/sciadv.aej0610","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:59:39Z","timestamp":1787767179000},"update-policy":"https:\/\/doi.org\/10.34133\/aaas_crossmark","source":"Crossref","is-referenced-by-count":0,"title":["A pro-natural product design strategy affords ester-based green fungicide candidates"],"prefix":"10.1126","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1685-9517","authenticated-orcid":true,"given":"Peng","family":"Lei","sequence":"first","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"Shaanxi Provincial Center for Biopesticide Engineering &amp; Technology, Northwest A&amp;F University, Yangling 712100, China."},{"name":"State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8793-8513","authenticated-orcid":true,"given":"Hanxiao","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9961-3817","authenticated-orcid":true,"given":"Xingxing","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Qu","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8904-0468","authenticated-orcid":true,"given":"Tan","family":"Dai","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-5150","authenticated-orcid":true,"given":"Jianqiang","family":"Miao","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-0879","authenticated-orcid":true,"given":"Yanqing","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"Shaanxi Provincial Center for Biopesticide Engineering &amp; Technology, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7859-9741","authenticated-orcid":true,"given":"Xili","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Plant Protection, Northwest A&amp;F University, Yangling 712100, China."},{"name":"State Key Laboratory for Crop Stress Resistance and High-Efficiency Production, Northwest A&amp;F University, Yangling 712100, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/d41586-025-01729-1","article-title":"Trade wars could affect food security in low-income nations","volume":"642","author":"Li H.","year":"2025","unstructured":"H. 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