{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:04:24Z","timestamp":1704845064065},"reference-count":7,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2620","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1945,3,16]]},"abstract":"<jats:p>\n            When rats on either a stock or a vitamin B deficient diet are given the amino acid\n            <jats:italic>dl<\/jats:italic>\n            -serine by stomach tube, there is a fall in the cocarboxylase concentration of the kidney. This organ exhibits marked damage. There is, also, a lessened tendency for cocarboxylase to disappear from the tissue homogenate upon anaerobic incubation\n            <jats:italic>in vitro.<\/jats:italic>\n            In animals on the stock diet, only, there is a recovery of the normal cocarboxylase level. The probable relation of these findings to the mechanism of the production of the injurious action of serine is discussed.\n          <\/jats:p>\n          <jats:p>We would like to acknowledge the helpful criticisms of Dr. C. Artom.<\/jats:p>","DOI":"10.1126\/science.101.2620.277","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T05:29:13Z","timestamp":1160026153000},"page":"277-279","source":"Crossref","is-referenced-by-count":2,"title":["The Changes in Rat Kidney Cocarboxylase Associated with the Injurious Effects of\n            <i>dl<\/i>\n            -Serine"],"prefix":"10.1126","volume":"101","author":[{"given":"William H.","family":"Fishman","sequence":"first","affiliation":[{"name":"Bowman Gray School of Medicine, N. C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wm. M.","family":"Govier","sequence":"additional","affiliation":[{"name":"Sharp and Dohme, Inc., Glenolden, Pa."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3181\/00379727-57-14767","volume":"57","year":"1944","unstructured":"ARTOM, C, Relation of route of administration to toxicity of dl-serine, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 57: 239 (1944).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_2_1","first-page":"10","volume":"3","year":"1944","unstructured":"FISHMAN, W. H., FEDERATION PROCEEDINGS 3: 10 (1944).","journal-title":"FEDERATION PROCEEDINGS"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0021-9258(18)45040-5","volume":"145","year":"1942","unstructured":"FISHMAN, W.H., Serine injury, JOURNAL OF BIOLOGICAL CHEMISTRY 145: 345 (1942).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_4_1","first-page":"240","volume":"79","year":"1943","unstructured":"GOVIER, W.M., Studies on shock induced by hemorrhage V The effect of cellular damage on the in vitro hydrolysis and synthesis of cocarboxylase by liver tissue, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 79: 240 (1943).","journal-title":"JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0021-9258(18)51439-3","volume":"138","year":"1941","unstructured":"GREEN, D.E., Carboxylase, JOURNAL OF BIOLOGICAL CHEMISTRY 138: 327 (1941).","journal-title":"JOURNAL OF BIOLOGICAL CHEMISTRY"},{"key":"e_1_2_1_6_1","first-page":"99","volume":"1","year":"1941","unstructured":"LIPMANN, F, Metabolic generation and utilization of phosphate bond energy, ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY 1: 99 (1941).","journal-title":"ADVANCES IN ENZYMOLOGY AND RELATED SUBJECTS OF BIOCHEMISTRY"},{"key":"e_1_2_1_7_1","first-page":"803","volume":"21","year":"1945","unstructured":"Morehead, R. P., American Journal of Pathology 21: 803 (1945).","journal-title":"American Journal of Pathology"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.101.2620.277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:40:53Z","timestamp":1704836453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.101.2620.277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1945,3,16]]},"references-count":7,"journal-issue":{"issue":"2620","published-print":{"date-parts":[[1945,3,16]]}},"alternative-id":["10.1126\/science.101.2620.277"],"URL":"https:\/\/doi.org\/10.1126\/science.101.2620.277","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1945,3,16]]}}}