{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:55:27Z","timestamp":1723060527352},"reference-count":7,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2621","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1945,3,23]]},"abstract":"<jats:p>\n            In this preliminary note we describe the results obtained by inoculation of the skin of the scrotum of four black rabbits with serous fluid expressed from an initial pinta lesion. The inoculation was made intradermally, as superficially as possible, with serous fluid rich in treponemata and diluted with normal salt solution. A papule appeared at the point of inoculation in one of the four rabbits on the 105th day. One hundred and fifteen days after inoculation the papule presented a circular erosion on an indurated base. The serous fluid expressed from this lesion contained numerous treponemata on dark-field examination, and these were easily impregnated by the Fontana-Tribondeau method. A volunteer inoculated with serous fluid expressed from the rabbit's lesion developed a typical initial pinta lesion at the point of inoculation, thus proving that the scrotal lesion of the rabbit was produced by\n            <jats:italic>Treponema carateum<\/jats:italic>\n            or\n            <jats:italic>Treponema herrejoni<\/jats:italic>\n            , the causal agent of pinta, mal del pinto or carate.\n          <\/jats:p>\n          <jats:p>Four rabbits inoculated with serous fluid from the scrotal lesion of the rabbit have not yet developed visible lesions.<\/jats:p>","DOI":"10.1126\/science.101.2621.309","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T05:29:13Z","timestamp":1160026153000},"page":"309-311","source":"Crossref","is-referenced-by-count":5,"title":["The Experimental Transmission of Pinta, Mal del Pinto or Carate to the Rabbit"],"prefix":"10.1126","volume":"101","author":[{"given":"Francisco","family":"Le\u00f3n-Blanco","sequence":"first","affiliation":[{"name":"Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Oteiza","sequence":"additional","affiliation":[{"name":"Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","first-page":"134","volume":"1","year":"1938","unstructured":"Curbelo, A., Revista de Ciencias Medicas 1: 134 (1938).","journal-title":"Revista de Ciencias Medicas"},{"key":"e_1_2_1_2_1","first-page":"165","volume":"35","year":"1941","unstructured":"Leon-Blanco, F., Archivo de la Sociedad de Estudios Clinicos de La Habana 35: 165 (1941).","journal-title":"Archivo de la Sociedad de Estudios Clinicos de La Habana"},{"key":"e_1_2_1_3_1","first-page":"257","volume":"38","year":"1944","unstructured":"Leon-Blanco, F., Archivo de la Sociedad de Estudios Clinicos de La Habana 38: 257 (1944).","journal-title":"Archivo de la Sociedad de Estudios Clinicos de La Habana"},{"key":"e_1_2_1_4_1","first-page":"5","volume":"6","year":"1940","unstructured":"Leon-Blanco, F., Revista de Medicina Tropical y Parasitologia, Bacteriologia, Clinica y Laboratorio 6: 5 (1940).","journal-title":"Revista de Medicina Tropical y Parasitologia, Bacteriologia, Clinica y Laboratorio"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jama.1943.02840450021005","volume":"123","year":"1943","unstructured":"LIEBERTHAL, E.P., Pinta (mal del pinto carate) In continental United States - Report of three cases with late manifestations and review of the salient features of the disease, JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 123: 619 (1943).","journal-title":"JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION"},{"key":"e_1_2_1_6_1","first-page":"224","volume":"2","year":"1936","unstructured":"Mooser, H., Boletin del Instituto de Higiene del Departamento de Salubridad Publica, Mexico 2: 224 (1936).","journal-title":"Boletin del Instituto de Higiene del Departamento de Salubridad Publica, Mexico"},{"key":"e_1_2_1_7_1","first-page":"221","volume":"4","year":"1944","unstructured":"Briceno Rossi, A. L., Bolet\u00edn del Laboratorio de la Cl\u00ednica Lu\u00eds Razetti 4: 221 (1944).","journal-title":"Bolet\u00edn del Laboratorio de la Cl\u00ednica Lu\u00eds Razetti"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.101.2621.309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:43:21Z","timestamp":1704836601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.101.2621.309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1945,3,23]]},"references-count":7,"journal-issue":{"issue":"2621","published-print":{"date-parts":[[1945,3,23]]}},"alternative-id":["10.1126\/science.101.2621.309"],"URL":"https:\/\/doi.org\/10.1126\/science.101.2621.309","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1945,3,23]]}}}