{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:54:56Z","timestamp":1758279296070},"reference-count":12,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2629","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1945,5,18]]},"abstract":"<jats:p>\n            The action of mushroom tyrosinase on the oxidation of the irritant principles of poison ivy and on related toxic compounds has been demonstrated by measuring oxygen consumption, color change, decrease in phenolic groups and reduction in dermatitis-producing properties of these compounds on human and guinea-pig skin. The action of tyrosinase on poison ivy toxicants occurs both\n            <jats:italic>in vitro<\/jats:italic>\n            and on the human skin.\n          <\/jats:p>","DOI":"10.1126\/science.101.2629.517","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T05:29:13Z","timestamp":1160026153000},"page":"517-518","source":"Crossref","is-referenced-by-count":9,"title":["Inactivation of the Irritant Toxicants of Poison Ivy and Related Compounds by Tyrosinase"],"prefix":"10.1126","volume":"101","author":[{"given":"Irwin W.","family":"Sizer","sequence":"first","affiliation":[{"name":"Department of Biology and Biological Engineering, Massachusetts Institute of Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens E.","family":"Prokesch","sequence":"additional","affiliation":[{"name":"Department of Biology and Biological Engineering, Massachusetts Institute of Technology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0083-6729(08)60286-1","volume":"2","year":"1944","unstructured":"Ansbacher, S., Vitamins and Hormones 2: 215 (1944).","journal-title":"Vitamins and Hormones"},{"key":"e_1_2_1_2_1","first-page":"144","year":"1936","unstructured":"Coghill, R. D., An Introduction to the Preparation and Identification of Organic Compounds: 144 (1936).","journal-title":"An Introduction to the Preparation and Identification of Organic Compounds"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1021\/ja01327a064","volume":"56","year":"1934","unstructured":"HILL, G.A., The toxic principle of the poison ivy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 56: 2736 (1934).","journal-title":"JOURNAL OF THE AMERICAN CHEMICAL SOCIETY"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3181\/00379727-38-9996","volume":"38","year":"1938","unstructured":"JACOBS, J.L., A method of testing guinea pigs for hypersensitiveness to Rhus toxicodendron, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE 38: 726 (1938).","journal-title":"PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE"},{"key":"e_1_2_1_5_1","first-page":"482","volume":"69","year":"1941","unstructured":"KEENEY, E.L., The diagnostic value of patch test made with an ether extract from fresh leaves and stems of the poison ivy plant, BULLETIN OF THE JOHNS HOPKINS HOSPITAL 69: 482 (1941).","journal-title":"BULLETIN OF THE JOHNS HOPKINS HOSPITAL"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.80.4.275","volume":"80","year":"1944","unstructured":"KEIL, H, The relation of chemical structure in catechol compounds and derivatives to poison ivy hypersensitiveness in man as shown by the patch test, JOURNAL OF EXPERIMENTAL MEDICINE 80: 275 (1944).","journal-title":"JOURNAL OF EXPERIMENTAL MEDICINE"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/cber.19220550123","volume":"55","year":"1922","unstructured":"MAJIMA, R, The main constituent of the Japanlack, VIII Announcement - The status of double bonds in the side chain of urushiol and the argumentation of the fact that urushiol is a mixture, BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT 55: 172 (1922).","journal-title":"BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT"},{"key":"e_1_2_1_8_1","first-page":"3058","volume":"64","year":"1942","unstructured":"Mason, H. 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