{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:40:55Z","timestamp":1792456855273,"version":"4.5.0"},"reference-count":3,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"2650","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[1945,10,12]]},"abstract":"<jats:p>\n            A new antibiotic \"bacitracin\" has been recovered from a strain of the\n            <jats:italic>B. subtilis<\/jats:italic>\n            group of organisms. It is neutral, water-soluble, non-toxic and relatively heat stable.\n            <jats:italic>In vitro<\/jats:italic>\n            it is active chiefly against Grampositive organisms, but the gonococcus and meningococcus are susceptible to its action. It is also active\n            <jats:italic>in vivo<\/jats:italic>\n            against experimentally produced hemolytic streptococcal infections in mice and gas gangrene infections in guinea pigs. Clinical use in hemolytic streptococcal and staphylococcal infections in man have given encouraging results.\n          <\/jats:p>","DOI":"10.1126\/science.102.2650.376","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T05:29:13Z","timestamp":1160026153000},"page":"376-377","source":"Crossref","is-referenced-by-count":249,"title":["Bacitracin: A New Antibiotic Produced by a Member of the\n            <i>B. subtilis<\/i>\n            Group"],"prefix":"10.1126","volume":"102","author":[{"given":"Balbina A.","family":"Johnson","sequence":"first","affiliation":[{"name":"Departments of Surgery and Biochemistry, College o Physicians and Surgeons, Columbia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Anker","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Biochemistry, College o Physicians and Surgeons, Columbia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Meleney","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Biochemistry, College o Physicians and Surgeons, Columbia University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_2_1_1_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.70.1.1"},{"key":"e_1_2_1_2_1","first-page":"134","volume":"2","year":"1944","unstructured":"Ganse, G. F., American Review of Soviet Medicine 2: 134 (1944).","journal-title":"American Review of Soviet Medicine"},{"key":"e_1_2_1_3_1","first-page":"297","volume":"4","year":"1944","unstructured":"JANSEN, E. F., ARCHIVES OF BIOCHEMISTRY 4: 297 (1944).","journal-title":"ARCHIVES OF BIOCHEMISTRY"}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.102.2650.376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T22:08:05Z","timestamp":1704838085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.102.2650.376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1945,10,12]]},"references-count":3,"journal-issue":{"issue":"2650","published-print":{"date-parts":[[1945,10,12]]}},"alternative-id":["10.1126\/science.102.2650.376"],"URL":"https:\/\/doi.org\/10.1126\/science.102.2650.376","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[1945,10,12]]}}}