{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:59:35Z","timestamp":1791039575445,"version":"4.1.0"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5506","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2001,2,9]]},"abstract":"<jats:p>\n                    During\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    vulval development, a signal from the anchor cell stimulates the RTK\/RAS\/MAPK (receptor tyrosine kinase\/RAS\/mitogen-activated protein kinase) signaling pathway in the closest vulval precursor cell P6.p to induce the primary fate. A lateral signal from P6.p then activates the Notch signaling pathway in the neighboring cells P5.p and P7.p to prevent them from adopting the primary fate and to specify the secondary fate. The MAP kinase phosphatase LIP-1 mediates this lateral inhibition of the primary fate. LIN-12\/NOTCH up-regulates\n                    <jats:italic>lip-1<\/jats:italic>\n                    transcription in P5.p and P7.p where LIP-1 inactivates the MAP kinase to inhibit primary fate specification. LIP-1 thus links the two signaling pathways to generate a pattern.\n                  <\/jats:p>","DOI":"10.1126\/science.1055642","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:47:44Z","timestamp":1027748864000},"page":"1055-1058","source":"Crossref","is-referenced-by-count":218,"title":["Notch Inhibition of RAS Signaling Through MAP Kinase Phosphatase LIP-1 During\n                    <i>C. elegans<\/i>\n                    Vulval Development"],"prefix":"10.1126","volume":"291","author":[{"given":"Thomas","family":"Berset","sequence":"first","affiliation":[{"name":"Division of Cancer Research, Department of Pathology, University of Zu\u0308rich, Schmelzbergstrasse 12, CH-8091 Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Fro\u0308hli","family":"Hoier","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Department of Pathology, University of Zu\u0308rich, Schmelzbergstrasse 12, CH-8091 Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Battu","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Department of Pathology, University of Zu\u0308rich, Schmelzbergstrasse 12, CH-8091 Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Canevascini","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Department of Pathology, University of Zu\u0308rich, Schmelzbergstrasse 12, CH-8091 Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, Department of Pathology, University of Zu\u0308rich, Schmelzbergstrasse 12, CH-8091 Zu\u0308rich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.1.6"},{"key":"e_1_3_1_3_2","unstructured":"For details on the materials and methods used see the supplementary information on Science Online at www.sciencemag.org\/cgi\/content\/full\/291\/5506\/1055\/DC1."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.160"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.147"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06269.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81096-X"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/356340a0"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/150.1.103"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.3.341"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81186-1"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/348503a0"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.24.3149"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/123.1.109"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(83)90377-X"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.5.1373"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.9.1947"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/335551a0"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.6.1083"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90317-8"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/375142a0"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.20.2715"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.770"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/147.3.1139"},{"key":"e_1_3_1_25_2","unstructured":"P. zur Lage"},{"key":"e_1_3_1_25_3","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.14.3149"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.126.20.4455"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(95)55031-3"},{"key":"e_1_3_1_28_2","unstructured":"gaIs36[HS-mpk-1(+)]; lip-1(lf); zhEx17 animals displayed an average induction of 3.0 ( n = 30); compare with Table 1 row 12. In one animal P6.p and P7.p adopted the 1\u00b0 fate."},{"key":"e_1_3_1_29_2","unstructured":"We thank E. Brunner A. Dutt E. Hafen and R. Klemenz for critical review of the manuscript; T. H\u00f6chli and T. B\u00e4chi for their help with microscopy; A. Fire for the GFP reporter plasmids and \u0394 pes-10 promoter; J. Wang and S. Kim for strains overexpressing mpk-1 ; and the Caenorhabditis elegans Genetics Center for providing some of the strains used. Supported by grants from the Sassella Foundation and the Swiss National Science Foundation (A.H.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1055642","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T18:02:55Z","timestamp":1704823375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1055642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,9]]},"references-count":29,"journal-issue":{"issue":"5506","published-print":{"date-parts":[[2001,2,9]]}},"alternative-id":["10.1126\/science.1055642"],"URL":"https:\/\/doi.org\/10.1126\/science.1055642","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,9]]}}}