{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:13:00Z","timestamp":1792739580529,"version":"4.5.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5522","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    is responsible for severe food-borne infections, but the mechanisms by which bacteria cross the intestinal barrier are unknown.\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    expresses a surface protein, internalin, that interacts with a host receptor, E-cadherin, to promote entry into human epithelial cells. Murine E-cadherin, in contrast to guinea pig E-cadherin, does not interact with internalin, excluding the mouse as a model for addressing internalin function in vivo. In guinea pigs and transgenic mice expressing human E-cadherin, internalin was found to mediate invasion of enterocytes and crossing of the intestinal barrier. These results illustrate how relevant animal models for human infections can be generated.\n                  <\/jats:p>","DOI":"10.1126\/science.1059852","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:52:41Z","timestamp":1027749161000},"page":"1722-1725","source":"Crossref","is-referenced-by-count":560,"title":["A Transgenic Model for Listeriosis: Role of Internalin in Crossing the Intestinal Barrier"],"prefix":"10.1126","volume":"292","author":[{"given":"Marc","family":"Lecuit","sequence":"first","affiliation":[{"name":"Unite\u0301 des Interactions Bacte\u0301ries-Cellules,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Vandormael-Pournin","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement, Unite\u0301 de Recherche Associe\u0301e CNRS 1960,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Lefort","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pharmacologie Cellulaire,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Huerre","sequence":"additional","affiliation":[{"name":"Unite\u0301 d'Histopathologie,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Gounon","sequence":"additional","affiliation":[{"name":"Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Interactions Bacte\u0301ries-Cellules,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Babinet","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Biologie du De\u0301veloppement, Unite\u0301 de Recherche Associe\u0301e CNRS 1960,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[{"name":"Unite\u0301 des Interactions Bacte\u0301ries-Cellules,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.1.1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199701093360204"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004273421702"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90009-N"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81070-3"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.13.1.119"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.14.3956"},{"key":"e_1_3_1_9_2","first-page":"694","volume":"26","author":"Racz P.","year":"1972","unstructured":"Racz P., Tenner K., M\u00e9r\u00f6 E., Lab. 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The purified 5545\u2013base pair DNA construct was microinjected in (C57BL\/6J \u00d7 SJL\/J)F 2 zygotes and reimplanted in pseudopregnant (C57BL\/6J \u00d7 CBA\/J)F 1 mice (9)."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.8.985"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.2.747-755.1998"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3797"},{"key":"e_1_3_1_16_2","first-page":"257","volume":"14","author":"Mayhew T. M.","year":"1999","unstructured":"Mayhew T. M., Myklebust R., Whybrow A., Jenkins R., Histol. Histopathol. 14, 257 (1999).","journal-title":"Histol. 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Takeichi for the gift of HECD1 hybridoma; J. I. Gordon for rat iFABP promoter DNA; V. R. Racaniello for human \u03b2-globin intron 2 DNA; H. Khun for the immunolabeling of tissue sections; and S. Dramsi G. Milon and H. Ohayon for help in preliminary experiments. These studies were supported by Association de Recherche sur le Cancer the European Economic Commission Minist\u00e8re de l'Education Nationale de l'Enseignement Sup\u00e9rieur et de la Recherche CNRS and Institut Pasteur. P.C. is an international investigator from the Howard Hughes Medical Institute."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1059852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T16:44:13Z","timestamp":1704818653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1059852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":26,"journal-issue":{"issue":"5522","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1126\/science.1059852"],"URL":"https:\/\/doi.org\/10.1126\/science.1059852","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1000372.13754","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1000372.3252","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}