{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:22:31Z","timestamp":1790799751866,"version":"4.1.0"},"reference-count":26,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5566","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2002,4,12]]},"abstract":"<jats:p>An outbreak of paralytic poliomyelitis occurred in the Dominican Republic (13 confirmed cases) and Haiti (8 confirmed cases, including 2 fatal cases) during 2000\u20132001. All but one of the patients were either unvaccinated or incompletely vaccinated children, and cases occurred in communities with very low (7 to 40%) rates of coverage with oral poliovirus vaccine (OPV). The outbreak was associated with the circulation of a derivative of the type 1 OPV strain, probably originating from a single OPV dose given in 1998\u20131999. The vaccine-derived poliovirus associated with the outbreak had biological properties indistinguishable from those of wild poliovirus.<\/jats:p>","DOI":"10.1126\/science.1068284","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:53:24Z","timestamp":1027763604000},"page":"356-359","source":"Crossref","is-referenced-by-count":476,"title":["Outbreak of Poliomyelitis in Hispaniola Associated with Circulating Type 1 Vaccine-Derived Poliovirus"],"prefix":"10.1126","volume":"296","author":[{"given":"Olen","family":"Kew","sequence":"first","affiliation":[{"name":"Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Morris-Glasgow","sequence":"additional","affiliation":[{"name":"Caribbean Epidemiology Centre (CAREC) Laboratory, Pan American Health Organization (PAHO), 16-18 Jamaica Boulevard, Federation Park, Port-of-Spain, Trinidad and Tobago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Landaverde","sequence":"additional","affiliation":[{"name":"Division of Vaccines and Immunization, PAHO, 525 Twenty-Third Street, N.W., Washington, DC 20037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Burns","sequence":"additional","affiliation":[{"name":"Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shaw","sequence":"additional","affiliation":[{"name":"Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zacar\u0131\u0301as","family":"Garib","sequence":"additional","affiliation":[{"name":"Ministry of Health, Avenida San Cristo\u0301bal esquina Tiradentes, Santo Domingo, Dominican Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Andre\u0301","sequence":"additional","affiliation":[{"name":"Ministry of Public Health, Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Blackman","sequence":"additional","affiliation":[{"name":"Caribbean Epidemiology Centre (CAREC) Laboratory, Pan American Health Organization (PAHO), 16-18 Jamaica Boulevard, Federation Park, Port-of-Spain, Trinidad and Tobago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Jason","family":"Freeman","sequence":"additional","affiliation":[{"name":"Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Jorba","sequence":"additional","affiliation":[{"name":"Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Sutter","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Disease Eradication Division, National Immunization Program, CDC, 1600 Clifton Road, Atlanta, GA 30333, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Tambini","sequence":"additional","affiliation":[{"name":"Division of Vaccines and Immunization, PAHO, 525 Twenty-Third Street, N.W., Washington, DC 20037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Venczel","sequence":"additional","affiliation":[{"name":"Division of Vaccines and Immunization, PAHO, 525 Twenty-Third Street, N.W., Washington, DC 20037, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pedreira","sequence":"additional","affiliation":[{"name":"PAHO, Calle Pepillo Salcedo, Plaza de la Salud, Santo Domingo, Dominican Republic."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Laender","sequence":"additional","affiliation":[{"name":"PAHO, Number 295 Avenue John Brown, Port-au-Prince, Haiti."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Virology II, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Department of Virology II, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Miyamura","sequence":"additional","affiliation":[{"name":"Department of Virology II, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrie","family":"van der Avoort","sequence":"additional","affiliation":[{"name":"Polio Laboratory, National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3720 BA, Bilthoven, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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W., Dowdle W. R., Bull. WHO 78, 347 (2000).","journal-title":"Bull. WHO"},{"key":"e_1_3_1_27_2","unstructured":"We thank N. Dybdahl-Sissoko N. Mishrik D. Moore M. Staples and A. J. Williams for characterization of poliovirus isolates before sequencing; J. Kim and J. Golub for sequencing some of the wild poliovirus type 1 isolates; R. Campagnoli for performing growth-rate studies of poliovirus isolates; P. Chenoweth for assistance with the mapping of the confirmed polio cases; L. Anderson V. C\u00e1ceres W. Dowdle H. Gary C. Maher and R. Sanders for helpful discussions; two anonymous reviewers for their constructive comments; and the virologists from the WHO Global Polio Laboratory Network for contributing the wild poliovirus isolates used in our comparisons."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1068284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:11:36Z","timestamp":1704852696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1068284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,12]]},"references-count":26,"journal-issue":{"issue":"5566","published-print":{"date-parts":[[2002,4,12]]}},"alternative-id":["10.1126\/science.1068284"],"URL":"https:\/\/doi.org\/10.1126\/science.1068284","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4,12]]}}}