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Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    and show that\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid\u2013binding adhesin (SabA) was isolated with the \u201cretagging\u201d method, and the underlying\n                    <jats:italic>sabA<\/jats:italic>\n                    gene (JHP662\/HP0725) was identified. The ability of many\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of\n                    <jats:italic>H<\/jats:italic>\n                    .\n                    <jats:italic>pylori<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1126\/science.1069076","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T15:34:46Z","timestamp":1033486486000},"page":"573-578","source":"Crossref","is-referenced-by-count":786,"title":["<i>Helicobacter pylori<\/i>\n                    SabA Adhesin in Persistent Infection and Chronic Inflammation"],"prefix":"10.1126","volume":"297","author":[{"given":"Jafar","family":"Mahdavi","sequence":"first","affiliation":[{"name":"Department of Odontology\/Oral Microbiology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Sonde\u0301n","sequence":"additional","affiliation":[{"name":"Department of Odontology\/Oral Microbiology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Hurtig","sequence":"additional","affiliation":[{"name":"Department of Odontology\/Oral Microbiology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad O.","family":"Olfat","sequence":"additional","affiliation":[{"name":"Department of Odontology\/Oral Microbiology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden."},{"name":"The Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Forsberg","sequence":"additional","affiliation":[{"name":"Department of Odontology\/Oral Microbiology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Roche","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Go\u0308teborg University, Box 440, SE-405 30 Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"\u212bngstro\u0308m","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Go\u0308teborg University, Box 440, SE-405 30 Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Larsson","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Go\u0308teborg University, Box 440, SE-405 30 Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Teneberg","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Go\u0308teborg University, Box 440, SE-405 30 Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Anders","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry, Go\u0308teborg University, Box 440, SE-405 30 Go\u0308teborg, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siiri","family":"Altraja","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cell Biology, Tartu University, EE-51010 Tartu, Estonia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkel","family":"Wadstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Medical Microbiology, Lund University, SE-223 62 Lund, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dangeruta","family":"Kersulyte","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas E.","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Dubois","sequence":"additional","affiliation":[{"name":"Laboratory of Gastrointestinal and Liver Studies, Department of Medicine, USUHS, Bethesda, MD 20814\u20134799, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer","family":"Petersson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Division of Medical Microbiology, Linko\u0308ping University, SE-581 85 Linko\u0308ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Eric","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Division of Medical Microbiology, Linko\u0308ping University, SE-581 85 Linko\u0308ping, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Norberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lindh","sequence":"additional","affiliation":[{"name":"IsoSep AB, Dalka\u0308rrsv. 11, SE-146 36 Tullinge, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertil B.","family":"Lundskog","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences\/Clinical Cytology, Ume\u00e5 University, SE-901 87 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Carlsson for critical reading of the manuscript. Supported by the Ume\u00e5 University Biotechnology Fund Swedish Society of Medicine\/Bengt Ihre's Fund Swedish Society for Medical Research Lion's Cancer Research Foundation at Ume\u00e5 University County Council of V\u00e4sterbotten Neose Glycoscience Research Award Grant (T.B.) Swedish Medical Research Council [11218 (T.B.) 12628 (S.T.) 3967 and 10435 (K.-A.K.) 05975 (L.H.) and 04723 (T.W.)] Swedish Cancer Society [4101-B00-03XAB (T.B.) and 4128-B99-02XAB (S.T.)] SSF programs \u201cGlycoconjugates in Biological Systems\u201d (T.B. S.T. and K.-A.K.) and \u201cInfection and Vaccinology\u201d (T.B. and K.-A.K.) J. C. Kempe Memorial Foundation (J. M. L. F. and M.H.) Wallenberg Foundation (S.T. and K.-A.K) Lundberg Foundation (K.-A.K.) ALF grant from Lund University Hospital (T.W.) and grants from the NIH [RO1 AI38166 RO3 AI49161 RO1 DK53727 (D.B.)] and from Washington University (P30 DK52574). These experiments were conducted according to the principles in the \u201cGuide for the Care and Use of Laboratory Animals \u201d Institute of Laboratory Animal Resources NRC HHS\/NIH Pub. No. 85\u201323. The opinions and assertions herein are private ones of the authors and are not to be construed as official or reflecting the views of the DOD the Uniformed Services University of the Health Sciences or the Defense Nuclear Agency."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1069076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:53:48Z","timestamp":1704837228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1069076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,26]]},"references-count":33,"journal-issue":{"issue":"5581","published-print":{"date-parts":[[2002,7,26]]}},"alternative-id":["10.1126\/science.1069076"],"URL":"https:\/\/doi.org\/10.1126\/science.1069076","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,26]]}}}