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Inhibition of CAR activity by administration of the inverse agonist ligand androstanol 1 hour after acetaminophen treatment blocked hepatotoxicity in wild type but not in CAR null mice. These results suggest an innovative therapeutic approach for treating the adverse effects of acetaminophen and potentially other hepatotoxic agents.<\/jats:p>","DOI":"10.1126\/science.1073502","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T04:55:53Z","timestamp":1034312153000},"page":"422-424","source":"Crossref","is-referenced-by-count":277,"title":["Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR"],"prefix":"10.1126","volume":"298","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S.","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200109000-00005"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198325030-00002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90851-U"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2215"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx00034a019"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90278-6"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90295-8"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/tx960159i"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)00023-Q"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(88)90592-9"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220176997"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.8081"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00656-4"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-101-3-403_1"},{"key":"e_1_3_1_16_2","first-page":"115","volume":"69","author":"Burk R. 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