{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:33:14Z","timestamp":1792251194136,"version":"4.4.0"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5584","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2002,8,16]]},"abstract":"<jats:p>Transient interactions of platelet-receptor glycoprotein Ib\u03b1 (GpIb\u03b1) and the plasma protein von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a role in haemostasis and thrombosis. Here we present structures of the GpIb\u03b1 amino-terminal domain and its complex with the VWF domain A1. In the complex, GpIb\u03b1 wraps around one side of A1, providing two contact areas bridged by an area of solvated charge interaction. The structures explain the effects of gain-of-function mutations related to bleeding disorders and provide a model for shear-induced activation. These detailed insights into the initial interactions in platelet adhesion are relevant to the development of antithrombotic drugs.<\/jats:p>","DOI":"10.1126\/science.107355","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T15:34:46Z","timestamp":1033486486000},"page":"1176-1179","source":"Crossref","is-referenced-by-count":475,"title":["Structures of Glycoprotein Ib\u03b1 and Its Complex with von Willebrand Factor A1 Domain"],"prefix":"10.1126","volume":"297","author":[{"given":"Eric G.","family":"Huizinga","sequence":"first","affiliation":[{"name":"Department of Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuko","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Laboratory,  Department of Haematology, Institute of Biomembranes, University Medical Center Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland A. P.","family":"Romijn","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Laboratory,  Department of Haematology, Institute of Biomembranes, University Medical Center Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion E.","family":"Schiphorst","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Laboratory,  Department of Haematology, Institute of Biomembranes, University Medical Center Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Laboratory,  Department of Haematology, Institute of Biomembranes, University Medical Center Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"Sixma","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Laboratory,  Department of Haematology, Institute of Biomembranes, University Medical Center Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet","family":"Gros","sequence":"additional","affiliation":[{"name":"Department of Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80983-6"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.40.23352"},{"key":"e_1_3_1_4_2","first-page":"327","volume":"47","author":"Goto S.","year":"2001","unstructured":"Goto S., Clin. 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