{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:32:04Z","timestamp":1791322324205,"version":"4.3.1"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5617","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,4,11]]},"abstract":"<jats:p>\n                    The CD8\n                    <jats:sup>+<\/jats:sup>\n                    cytotoxic T cell response to pathogens is thought to be CD4\n                    <jats:sup>+<\/jats:sup>\n                    helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells mount a primary CD8 response to\n                    <jats:italic>Listeria monocytogenes<\/jats:italic>\n                    equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from normal mice can respond rapidly, but memory CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.\n                  <\/jats:p>","DOI":"10.1126\/science.1083317","type":"journal-article","created":{"date-parts":[[2003,4,10]],"date-time":"2003-04-10T16:24:47Z","timestamp":1049991887000},"page":"339-342","source":"Crossref","is-referenced-by-count":938,"title":["Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help"],"prefix":"10.1126","volume":"300","author":[{"given":"Joseph C.","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Bevan","sequence":"additional","affiliation":[{"name":"Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/30996"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/31002"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/30989"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.083001.084359"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01201-1"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/353180a0"},{"key":"e_1_3_1_8_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064571"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.4049\/jimmunol.153.7.3116","volume":"153","author":"Ladel C. 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This work was supported by NIH grant AI 19335 and the Howard Hughes Medical Institute."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1083317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:27:49Z","timestamp":1704835669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1083317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,11]]},"references-count":28,"journal-issue":{"issue":"5617","published-print":{"date-parts":[[2003,4,11]]}},"alternative-id":["10.1126\/science.1083317"],"URL":"https:\/\/doi.org\/10.1126\/science.1083317","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1013630.191505","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013630.193928","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013630.201835","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,11]]}}}