{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:57:06Z","timestamp":1791295026066,"version":"4.1.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5630","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,7,11]]},"abstract":"<jats:p>Direct interaction between platelet receptor glycoprotein Ib\u03b1 (GpIb\u03b1) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIb\u03b1-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIb\u03b1-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIb\u03b1 with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIb\u03b1-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIb\u03b1-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.<\/jats:p>","DOI":"10.1126\/science.1083917","type":"journal-article","created":{"date-parts":[[2003,7,10]],"date-time":"2003-07-10T21:18:38Z","timestamp":1057871918000},"page":"222-226","source":"Crossref","is-referenced-by-count":124,"title":["Crystal Structure of the GpIb\u03b1-Thrombin Complex Essential for Platelet Aggregation"],"prefix":"10.1126","volume":"301","author":[{"given":"John J.","family":"Dumas","sequence":"first","affiliation":[{"name":"Department of Chemical and Screening Sciences, Wyeth, 200 Cambridge Park Drive, Cambridge, MA 02140, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemical and Screening Sciences, Wyeth, 200 Cambridge Park 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The coordinates for the GpIb\u03b1-thrombin complex have been deposited in the Protein Data Bank with the accession code 1P8V."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1083917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:49:11Z","timestamp":1704854951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1083917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,11]]},"references-count":44,"journal-issue":{"issue":"5630","published-print":{"date-parts":[[2003,7,11]]}},"alternative-id":["10.1126\/science.1083917"],"URL":"https:\/\/doi.org\/10.1126\/science.1083917","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,11]]}}}