{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:36:31Z","timestamp":1791142591387,"version":"4.1.0"},"reference-count":21,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5629","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,7,4]]},"abstract":"<jats:p>\n                    The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the inner ear. The central element of the HC's transduction apparatus is a mechanically gated ion channel of unknown identity. Here we report that the zebrafish ortholog of\n                    <jats:italic>Drosophila no mechanoreceptor potential C<\/jats:italic>\n                    (\n                    <jats:italic>nompC<\/jats:italic>\n                    ), which encodes a transient receptor potential (TRP) channel, is critical for HC mechanotransduction. In zebrafish larvae,\n                    <jats:italic>nompC<\/jats:italic>\n                    is selectively expressed in sensory HCs. Morpholino-mediated removal of\n                    <jats:italic>nompC<\/jats:italic>\n                    function eliminated transduction-dependent endocytosis and electrical responses in HCs, resulting in larval deafness and imbalance. These observations indicate that\n                    <jats:italic>nompC<\/jats:italic>\n                    encodes a vertebrate HC mechanotransduction channel.\n                  <\/jats:p>","DOI":"10.1126\/science.1084370","type":"journal-article","created":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T20:24:43Z","timestamp":1055795083000},"page":"96-99","source":"Crossref","is-referenced-by-count":294,"title":["NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction"],"prefix":"10.1126","volume":"301","author":[{"given":"Samuel","family":"Sidi","sequence":"first","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Entwicklungsbiologie, Spemannstrasse 35, 72076 Tu\u0308bingen, Germany. Max-Planck-Institut fu\u0308r Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer W.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Entwicklungsbiologie, Spemannstrasse 35, 72076 Tu\u0308bingen, Germany. Max-Planck-Institut fu\u0308r Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nicolson","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fu\u0308r Entwicklungsbiologie, Spemannstrasse 35, 72076 Tu\u0308bingen, Germany. Max-Planck-Institut fu\u0308r Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/341397a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-05-00962.1983"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35093011"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00344-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(84)90041-8"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90343-X"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"C. Montell Sci. STKE 2003 re1 (2003) (http:\/\/stke.sciencemag.org\/cgi\/content\/full\/OC_sigtrans;2001\/90\/re1).","DOI":"10.1126\/scisignal.902001re1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077544"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81232-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069259"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/18906"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-21-08259.1997"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00143-4"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5461.2229"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90437-5"},{"key":"e_1_3_2_17_2","unstructured":"S. Sidi et al . data not shown."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.1053"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4695(19991115)41:3<424::AID-NEU10>3.0.CO;2-G"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-05-00942.1983"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80455-9"},{"key":"e_1_3_2_22_2","unstructured":"Supported by the Max Planck Society and the Deutsche Sonderforschungsbereich 430. We thank W. Denk for technical support."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1084370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:40:24Z","timestamp":1704836424000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1084370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,4]]},"references-count":21,"journal-issue":{"issue":"5629","published-print":{"date-parts":[[2003,7,4]]}},"alternative-id":["10.1126\/science.1084370"],"URL":"https:\/\/doi.org\/10.1126\/science.1084370","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1013941.195915","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013941.192507","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013941.192362","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013941.192559","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,4]]}}}