{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:32:18Z","timestamp":1792737138166,"version":"4.5.0"},"reference-count":28,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5631","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,7,18]]},"abstract":"<jats:p>\n                    The human-specific bacterial pathogen\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    is a major cause of sepsis and\/or meningitis. The pili of\n                    <jats:italic>N. meningitidis<\/jats:italic>\n                    interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease.\n                  <\/jats:p>","DOI":"10.1126\/science.1086476","type":"journal-article","created":{"date-parts":[[2003,7,17]],"date-time":"2003-07-17T16:32:21Z","timestamp":1058459541000},"page":"373-375","source":"Crossref","is-referenced-by-count":155,"title":["CD46 in Meningococcal Disease"],"prefix":"10.1126","volume":"301","author":[{"given":"Linda","family":"Johansson","sequence":"first","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rytko\u0308nen","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bergman","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Albiger","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Ka\u0308llstro\u0308m","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Ho\u0308kfelt","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Agerberth","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Beth","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Microbiology and Tumor Biology Center, Nobels va\u0308g 16, Box 280, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Department of Medical Biochemistry and Biophysics, Department of Cell and Molecular Biology, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Molecular Medicine Program, Mayo Clinic, Guggenheim 1838, 200 First Street SW, Rochester, MN 55905, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1046\/j.1365-2958.1999.01416.x","volume":"32","year":"1999","unstructured":"X. Nassif, C. Pujol, P. Morand, E. Eug\u00e8ne, Mol. Microbiol.32, 1124 (1999).","journal-title":"Mol. Microbiol."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1365-2958.1997.4841857.x","volume":"25","year":"1997","unstructured":"H. K\u00e4llstr\u00f6m, M. K. Liszewski, J. P. Atkinson, A.-B. Jonsson, Mol. Microbiol.25, 639 (1997).","journal-title":"Mol. 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This work was supported by grants from the Swedish Research Council (Dnr 10846 Dnr 11217-08A and Dnr 04X-2887) Swedish Cancer Society Magnus Bergvalls Stiftelse Strategic Foundation (I & V program) Aventis Karolinska Institutet the Marianne and Marcus Wallenberg Foundation the Knut and Alice Wallenberg Foundation and BristolMyers Squibb (unrestricted neuroscience grant). B. Albiger was supported by a postdoctoral fellowship from Stiftelsen Wenner Grenska Samfundet."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1086476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:55:45Z","timestamp":1704837345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1086476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,18]]},"references-count":28,"journal-issue":{"issue":"5631","published-print":{"date-parts":[[2003,7,18]]}},"alternative-id":["10.1126\/science.1086476"],"URL":"https:\/\/doi.org\/10.1126\/science.1086476","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1014515.194310","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1014515.197252","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,18]]}}}