{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:00:50Z","timestamp":1790233250738,"version":"4.1.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5651","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,12,5]]},"abstract":"<jats:p>\n            In vitro studies have indicated that reactive oxygen species (ROS) and the oxidation of signaling molecules are important mediators of signal transduction. We have identified two pathways by which the altered redox chemistry of the\n            <jats:italic>clk-1<\/jats:italic>\n            mutants of\n            <jats:italic>Caenorhabditis elegans<\/jats:italic>\n            acts in vivo on germline development. One pathway depends on the oxidation of an analog of vertebrate low density lipoprotein (LDL) and acts on the germline through the Ack-related tyrosine kinase (ARK-1) kinase and inositol trisphosphate (IP\n            <jats:sub>3<\/jats:sub>\n            ) signaling. The other pathway is the oncogenic\n            <jats:italic>ras<\/jats:italic>\n            signaling pathway, whose action on germline as well as vulval development appears to be modulated by cytoplasmic ROS.\n          <\/jats:p>","DOI":"10.1126\/science.1087167","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T22:22:53Z","timestamp":1070576573000},"page":"1779-1782","source":"Crossref","is-referenced-by-count":103,"title":["Redox Regulation of Germline and Vulval Development in\n            <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1126","volume":"302","author":[{"given":"Yukimasa","family":"Shibata","sequence":"first","affiliation":[{"name":"Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montre\u0301al, Que\u0301bec, Canada, H3A 1B1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Branicky","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montre\u0301al, Que\u0301bec, Canada, H3A 1B1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Oviedo","family":"Landaverde","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montre\u0301al, Que\u0301bec, Canada, H3A 1B1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siegfried","family":"Hekimi","sequence":"additional","affiliation":[{"name":"Department of Biology, McGill University, 1205 Avenue Docteur Penfield, Montre\u0301al, Que\u0301bec, Canada, H3A 1B1."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025203"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(03)00002-4"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5306.1649"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0389"},{"key":"e_1_3_2_7_2","first-page":"S60","volume":"71","year":"1993","unstructured":"L. Ernster, P. Forsmark-Andree, Clin. Invest.71 (no. 8), S60 (1993).","journal-title":"Clin. Invest."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5302.980"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000889200"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.421"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109034200"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/139.3.1247"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204758200"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02282-2"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/159.3.997"},{"key":"e_1_3_2_16_2","unstructured":"The materials and methods are included in the supporting materials on Science Online."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.20.1.663"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30267-4"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/365065a0"},{"key":"e_1_3_2_20_2","unstructured":"Y. Shibata S. Hekimi unpublished observations."},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02101283"},{"key":"e_1_3_2_22_2","unstructured":"Y. Shibata R. Branicky I. O. Landaverde S. Hekimi unpublished observations."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.12.4311"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9388"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/hq0701.092092"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00001-8"},{"key":"e_1_3_2_27_2","unstructured":"See http:\/\/nematode.lab.nig.ac.jp\/cgi-bin\/db\/ShowCloneInfo.sh?clone=596e4"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80945-9"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/149.4.1809"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(98)01592-3"},{"key":"e_1_3_2_31_2","unstructured":"Y. Shibata S. Hekimi unpublished observations."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068836"},{"key":"e_1_3_2_33_2","unstructured":"We thank F. Bussi\u00e8re for technical assistance; C. B\u00e9nard for reading the manuscript; A. Coulson A. Fire and Y. Kohara for providing clones; and the Caenorhabditis Genetics Center (funded by the NIH National Center for Research Resources) for providing strains. S.H. is scientist with the Canadian Institutes of Health Research and R.B. is supported by a McGill Major Fellowship. The GenBank accession number for the dsc-4 cDNA is AY428645."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1087167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T02:43:44Z","timestamp":1704854624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1087167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,5]]},"references-count":32,"journal-issue":{"issue":"5651","published-print":{"date-parts":[[2003,12,5]]}},"alternative-id":["10.1126\/science.1087167"],"URL":"https:\/\/doi.org\/10.1126\/science.1087167","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,5]]}}}