{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:42:48Z","timestamp":1792680168082,"version":"4.5.0"},"reference-count":41,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5644","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,10,17]]},"abstract":"<jats:p>\n                    We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as \u00ce\u00b3 chain (\u00ce\u00b3c) deficiency] in 9 out of 10 patients by retrovirus-mediated \u00ce\u00b3c gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncontrolled exponential clonal proliferation of mature T cells (with \u00ce\u00b3\u00ce\u00b4+ or \u00ce\u00b1\u00ce\u00b2+ T cell receptors) has occurred in the two youngest patients. Both patients' clones showed retrovirus vector integration in proximity to the\n                    <jats:italic>LMO2<\/jats:italic>\n                    proto-oncogene promoter, leading to aberrant transcription and expression of\n                    <jats:italic>LMO2<\/jats:italic>\n                    . Thus, retrovirus vector insertion can trigger deregulated premalignant cell proliferation with unexpected frequency, most likely driven by retrovirus enhancer activity on the\n                    <jats:italic>LMO2<\/jats:italic>\n                    gene promoter.\n                  <\/jats:p>","DOI":"10.1126\/science.1088547","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T17:09:09Z","timestamp":1066324149000},"page":"415-419","source":"Crossref","is-referenced-by-count":3119,"title":["<i>LMO2<\/i>\n                    -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1"],"prefix":"10.1126","volume":"302","author":[{"given":"S.","family":"Hacein-Bey-Abina","sequence":"first","affiliation":[{"name":"INSERM Unit 429, Cedex 15, France."},{"name":"Department de Biotherapie Assistance Publique\u00e2\u0080\u0093Hopitaux de Paris, Cedex 15, France."},{"name":"Laboratoire de Cytoge\u00cc\u0081ne\u00cc\u0081tique, Cedex 15, France."},{"name":"Laboratoire Central d'He\u00cc\u0081matologie and CNRS Unite\u00cc\u0081 de Recherche Associe\u00cc\u0081e 1461, Universite\u00cc\u0081 Paris V, Cedex 15, France."},{"name":"Unite\u00cc\u0081 d'Immunologie et d'He\u00cc\u0081matologie Pe\u00cc\u0081diatriques, Ho\u00cc\u0082pital Necker, 75743 Paris, Cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Von Kalle","sequence":"additional","affiliation":[{"name":"INSERM Unit 429, Cedex 15, France."},{"name":"Department de Biotherapie Assistance Publique\u00e2\u0080\u0093Hopitaux de Paris, Cedex 15, France."},{"name":"Laboratoire de Cytoge\u00cc\u0081ne\u00cc\u0081tique, Cedex 15, France."},{"name":"Laboratoire Central d'He\u00cc\u0081matologie and CNRS Unite\u00cc\u0081 de Recherche Associe\u00cc\u0081e 1461, Universite\u00cc\u0081 Paris V, Cedex 15, France."},{"name":"Unite\u00cc\u0081 d'Immunologie et d'He\u00cc\u0081matologie Pe\u00cc\u0081diatriques, Ho\u00cc\u0082pital Necker, 75743 Paris, Cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"INSERM Unit 429, Cedex 15, France."},{"name":"Department de Biotherapie Assistance Publique\u00e2\u0080\u0093Hopitaux de Paris, Cedex 15, France."},{"name":"Laboratoire de Cytoge\u00cc\u0081ne\u00cc\u0081tique, Cedex 15, France."},{"name":"Laboratoire Central d'He\u00cc\u0081matologie and CNRS Unite\u00cc\u0081 de Recherche Associe\u00cc\u0081e 1461, Universite\u00cc\u0081 Paris V, Cedex 15, France."},{"name":"Unite\u00cc\u0081 d'Immunologie et d'He\u00cc\u0081matologie Pe\u00cc\u0081diatriques, Ho\u00cc\u0082pital Necker, 75743 Paris, Cedex 15, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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