{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:43:48Z","timestamp":1792727028164,"version":"4.5.0"},"reference-count":29,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5645","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,10,24]]},"abstract":"<jats:p>\n                    Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    . We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks in families with many cases. Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%. Lifetime risks of ovarian cancer were 54% for\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and 23% for\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset.\n                  <\/jats:p>","DOI":"10.1126\/science.1088759","type":"journal-article","created":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T22:34:42Z","timestamp":1066948482000},"page":"643-646","source":"Crossref","is-referenced-by-count":1899,"title":["Breast and Ovarian Cancer Risks Due to Inherited Mutations in\n                    <i>BRCA1<\/i>\n                    and\n                    <i>BRCA2<\/i>"],"prefix":"10.1126","volume":"302","author":[{"given":"Mary-Claire","family":"King","sequence":"first","affiliation":[{"name":"Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA."},{"name":"Sarah Lawrence College Graduate Program in Human Genetics, Bronxville, NY 10708, USA."},{"name":"The New York Breast Cancer Study Group includes Albert Einstein College of Medicine\/Montefiore Medical Center (Myrna Ben-Yishay, Janice P. Dutcher, Susan J. Gross, Carolyn D. Runowicz, Usha Venkatraj); Beth Israel Medical Center (Katherine Daley, Gayna Havens, Victor B. Penchaszadeh, Bert Petersen, Peter Pressman, Diana Punales-Morejon); Columbia Presbyterian Medical Center, Columbia University (Karen H. Antman, Donna Russo); Englewood Hospital and Medical Center (Sherry L. Campbell Grumet);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan H.","family":"Marks","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA."},{"name":"Sarah Lawrence College Graduate Program in Human Genetics, Bronxville, NY 10708, USA."},{"name":"The New York Breast Cancer Study Group includes Albert Einstein College of Medicine\/Montefiore Medical Center (Myrna Ben-Yishay, Janice P. Dutcher, Susan J. Gross, Carolyn D. Runowicz, Usha Venkatraj); Beth Israel Medical Center (Katherine Daley, Gayna Havens, Victor B. Penchaszadeh, Bert Petersen, Peter Pressman, Diana Punales-Morejon); Columbia Presbyterian Medical Center, Columbia University (Karen H. Antman, Donna Russo); Englewood Hospital and Medical Center (Sherry L. Campbell Grumet);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Mandell","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA."},{"name":"Sarah Lawrence College Graduate Program in Human Genetics, Bronxville, NY 10708, USA."},{"name":"The New York Breast Cancer Study Group includes Albert Einstein College of Medicine\/Montefiore Medical Center (Myrna Ben-Yishay, Janice P. Dutcher, Susan J. Gross, Carolyn D. Runowicz, Usha Venkatraj); Beth Israel Medical Center (Katherine Daley, Gayna Havens, Victor B. Penchaszadeh, Bert Petersen, Peter Pressman, Diana Punales-Morejon); Columbia Presbyterian Medical Center, Columbia University (Karen H. Antman, Donna Russo); Englewood Hospital and Medical Center (Sherry L. Campbell Grumet);..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","unstructured":"L. A. G. Ries M. P. Eisner C. L. Kasary Eds. SEER Cancer Statistics Review 1973\u00e2\u0080\u00931999 (National Cancer Institute Bethesda 2002)."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc726"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/301749"},{"key":"e_1_3_1_5_2","first-page":"1059","volume":"60","year":"1997","unstructured":"E. Levy-Lahad et al., Am. J. Hum. Genet.60, 1059 (1997).","journal-title":"Am. J. Hum. 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Lauder for ongoing support. The authors are grateful to the more than 100 graduate students of the Human Genetics Program at Sarah Lawrence College who were instrumental in bringing this project to fruition."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1088759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:46:18Z","timestamp":1704836778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1088759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,24]]},"references-count":29,"journal-issue":{"issue":"5645","published-print":{"date-parts":[[2003,10,24]]}},"alternative-id":["10.1126\/science.1088759"],"URL":"https:\/\/doi.org\/10.1126\/science.1088759","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016521.200892","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,24]]}}}