{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:20:49Z","timestamp":1792293649160,"version":"4.4.0"},"reference-count":44,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5664","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,3,12]]},"abstract":"<jats:p>To what extent do all brains work alike during natural conditions? We explored this question by letting five subjects freely view half an hour of a popular movie while undergoing functional brain imaging. Applying an unbiased analysis in which spatiotemporal activity patterns in one brain were used to \u201cmodel\u201d activity in another brain, we found a striking level of voxel-by-voxel synchronization between individuals, not only in primary and secondary visual and auditory areas but also in association cortices. The results reveal a surprising tendency of individual brains to \u201ctick collectively\u201d during natural vision. The intersubject synchronization consisted of a widespread cortical activation pattern correlated with emotionally arousing scenes and regionally selective components. The characteristics of these activations were revealed with the use of an open-ended \u201creverse-correlation\u201d approach, which inverts the conventional analysis by letting the brain signals themselves \u201cpick up\u201d the optimal stimuli for each specialized cortical area.<\/jats:p>","DOI":"10.1126\/science.1089506","type":"journal-article","created":{"date-parts":[[2004,3,11]],"date-time":"2004-03-11T17:06:44Z","timestamp":1079024804000},"page":"1634-1640","source":"Crossref","is-referenced-by-count":1695,"title":["Intersubject Synchronization of Cortical Activity During Natural Vision"],"prefix":"10.1126","volume":"303","author":[{"given":"Uri","family":"Hasson","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Department of Computer Science, Tel Aviv University, Tel Aviv 61390, Israel."},{"name":"Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Nir","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Department of Computer Science, Tel Aviv University, Tel Aviv 61390, Israel."},{"name":"Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifat","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Department of Computer Science, Tel Aviv University, Tel Aviv 61390, Israel."},{"name":"Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Fuhrmann","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Department of Computer Science, Tel Aviv University, Tel Aviv 61390, Israel."},{"name":"Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Malach","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel."},{"name":"Department of Computer Science, Tel Aviv University, Tel Aviv 61390, Israel."},{"name":"Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem 91904, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00074-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-18-07060.1997"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00040-0"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00144-2"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9379"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1167\/2.10.12"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00339.2003"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-01340.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00095-3"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5365.921"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/88486"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10153"},{"key":"e_1_3_2_14_2","unstructured":"L. Vincenzoni S. Leone The Good the Bad and the Ugly S. Leone Director 161 min Metro-Goldwyn Mayer (MGM) 1966."},{"key":"e_1_3_2_15_2","unstructured":"Materials and methods are available on Science Online. BrainShow.exe is available at www.weizmann.ac.il\/neurobiology\/labs\/malach\/ReverseCorrelation."},{"key":"e_1_3_2_16_2","unstructured":"In order to search for correlation between two corresponding regions across subjects (intersubject correlation) we first aligned all brains into Talairach coordinate system and used a Gaussian filter of 12 mm full width at half maximum value (FWHM) to the data [similar results were obtained with the use of 8 mm FWHM ( 17 )]. To remove preprocessing artifacts we excluded the first and last 10 time points of the experiment from the analysis. We then used the time course of each voxel of the source subject as a GLM predictor for modeling the activity in the corresponding voxel of the target subject. Only voxels whose P value was no more than 0.05 (corrected) were considered significant."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076262"},{"key":"e_1_3_2_18_2","unstructured":"U. Hasson Y. Nir I. Levy G. Fuhrmann R. Malach unpublished data."},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1987.58.6.1187"},{"key":"e_1_3_2_20_2","unstructured":"For the reverse correlation each given time course was z-normalized and smoothed with a moving average of three time points. A t test was applied to each time point along the averaged time course and only time points that were significantly different ( P < 0.05) from the average mean value (i.e. 0) were included in the analysis (colored in Figs. 3 and 4). With the use of the inhouse \u201cBrain Show\u201d software we then reconstructed a short \u201cmovie\u201d composed of the frames that led to the highest BOLD signal in each specific region assuming our standard hemodynamic lag of 3 s. We then examined those movies in an attempt to evaluate each region's functional specialization under natural viewing conditions."},{"key":"e_1_3_2_21_2","unstructured":"To remove the nonselective component from the movie data set for the region-specific time course we z-normalized the common \u201ctime course\u201d of each subject (Fig. 2B) smoothed it with a moving average of three time points and then used it as a GLM predictor which was fitted to the entire data set of the subject. The residual time course (which was not explained by the predictor) was saved as a new time course."},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(00)01482-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80546-2"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/33402"},{"key":"e_1_3_2_26_2","unstructured":"To view all frames associated with the peaks of activation in the fusiform face-related building-related and PCS regions use the DVD of ( 13 ) and BrainShow.exe ( 14 )."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063414"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00642-6"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02188.1998"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/71152"},{"key":"e_1_3_2_31_2","unstructured":"A. R. Damasio The Feeling of What Happens: Body and Emotion in the Making of Consciousness (Harcourt Brace New York ed.1 1999)."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063736"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg216"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/77722"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80832-6"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1995.73.1.218"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/7280"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/44134"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80659-5"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80037-2"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0926-6410(95)00038-0"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00598.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2601(01)80003-4"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00446-9"},{"key":"e_1_3_2_45_2","unstructured":"This study was funded by the Benoziyo Center. We thank the Wohl Institute for Advanced Imaging in the Tel-Aviv Sourasky Medical Center; M. Behrmann K. Grill-Spector G. Avidan M. Peleg and S. Gilaie-Dotan for fruitful discussions and comments; R. Goebel and D. Paserman for helping with the intersubject analysis; M. Harel for three-dimensional brain reconstructions; E. Okon for technical assistance; E. Malach for programming the \u201cbrain-show\u201d reverse-correlation analysis tool; and R. Mukamel for software development. We thank C. Eastwood and H. Grimaldi for kindly providing us with permission to use the frames."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1089506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:11:12Z","timestamp":1704841872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1089506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,12]]},"references-count":44,"journal-issue":{"issue":"5664","published-print":{"date-parts":[[2004,3,12]]}},"alternative-id":["10.1126\/science.1089506"],"URL":"https:\/\/doi.org\/10.1126\/science.1089506","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1018014.206682","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1018014.206610","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1018014.207580","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3,12]]}}}