{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:22:48Z","timestamp":1791285768895,"version":"4.1.0"},"reference-count":16,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5668","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,4,9]]},"abstract":"<jats:p>Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein\u2013coupled receptor named GPRA (G protein\u2013coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and asthmatic individuals. In three cohorts from Finland and Canada, single nucleotide polymorphism\u2013tagged haplotypes associated with high serum immunoglobulin E or asthma. The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma.<\/jats:p>","DOI":"10.1126\/science.1090010","type":"journal-article","created":{"date-parts":[[2004,4,8]],"date-time":"2004-04-08T20:23:26Z","timestamp":1081455806000},"page":"300-304","source":"Crossref","is-referenced-by-count":358,"title":["Characterization of a Common Susceptibility Locus for Asthma-Related Traits"],"prefix":"10.1126","volume":"304","author":[{"given":"Tarja","family":"Laitinen","sequence":"first","affiliation":[{"name":"GeneOS Limited, 00251 Helsinki, Finland."},{"name":"Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Department of Anatomy, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Finnish Genome Center, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Department of Biosciences at Novum and Clinical Research Centre, Karolinska Institutet, 14157 Huddinge, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Polvi","sequence":"additional","affiliation":[{"name":"GeneOS Limited, 00251 Helsinki, Finland."},{"name":"Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Department of Anatomy, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Finnish Genome Center, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Department of Biosciences at Novum and Clinical Research Centre, Karolinska Institutet, 14157 Huddinge, Sweden."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Rydman","sequence":"additional","affiliation":[{"name":"GeneOS Limited, 00251 Helsinki, Finland."},{"name":"Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland."},{"name":"Department of Anatomy, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, 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Pulkkinen et al . unpublished observations."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00878"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1166"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1256"},{"key":"e_1_3_1_17_2","unstructured":"We thank M. Daly M. Dixon P. Kauppi S. Knaappila R. Lehtinen H. Turunen and the staff of GeneOS Limited and Finnish Genome Center for their expertise and help. This study has been supported by Academy of Finland Finnish National Technology Agency Tekes Finnish Antituberculosis Association Foundation Sigrid Jus\u00e9lius Foundation and GeneOS Limited. The French Canadian asthma research program was supported by Canadian Institutes of Health Research and the Burroughs Wellcome Fund. J.K. is a member of Biocentrum Helsinki and Center of Excellence for Disease Genetics at University of Helsinki. L.A.L. and J.K. hold equity in GeneOS Limited and are on the board of directors."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1090010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:43:36Z","timestamp":1704861816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1090010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,9]]},"references-count":16,"journal-issue":{"issue":"5668","published-print":{"date-parts":[[2004,4,9]]}},"alternative-id":["10.1126\/science.1090010"],"URL":"https:\/\/doi.org\/10.1126\/science.1090010","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,9]]}}}