{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:55:04Z","timestamp":1792587304867,"version":"4.5.0"},"reference-count":23,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5647","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,11,7]]},"abstract":"<jats:p>\n                    Activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. We now show that\n                    <jats:italic>Eomesodermin<\/jats:italic>\n                    (\n                    <jats:italic>Eomes<\/jats:italic>\n                    ), a paralogue of\n                    <jats:italic>T-bet<\/jats:italic>\n                    , is induced in effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, including interferon-\u03b3 (IFN-\u03b3), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. We suggest that\n                    <jats:italic>Eomesodermin<\/jats:italic>\n                    is likely to complement the actions of\n                    <jats:italic>T-bet<\/jats:italic>\n                    and act as a key regulatory gene in the development of cell-mediated immunity.\n                  <\/jats:p>","DOI":"10.1126\/science.1090148","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T17:23:30Z","timestamp":1068139410000},"page":"1041-1043","source":"Crossref","is-referenced-by-count":911,"title":["Control of Effector CD8\n                    <sup>+<\/sup>\n                    T Cell Function by the Transcription Factor\n                    <i>Eomesodermin<\/i>"],"prefix":"10.1126","volume":"302","author":[{"given":"Erika L.","family":"Pearce","sequence":"first","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan C.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisla\u0302ine A.","family":"Martins","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie M.","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S.","family":"Hutchins","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie P.","family":"Zediak","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Banica","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"DiCioccio","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrick A.","family":"Gross","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chai-an","family":"Mao","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nezih","family":"Cereb","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullia","family":"Lindsten","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Rossant","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Hunter","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Reiner","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA."},{"name":"Samuel Lunenfeld Research Institute, and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada M5G 1X5."},{"name":"Histogenetics, and Center for Genetic Polymorphism, Ossining, NY 10562, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80240-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80702-3"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065543"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059835"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni807"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni904"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079490"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni909"},{"key":"e_1_3_1_10_2","unstructured":"Supporting online material is available on Science online."},{"key":"e_1_3_1_11_2","unstructured":"N. Cereb G. A. Martins S. L. Reiner S. Y. Yang manuscript in preparation."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81794-8"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/35003601"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5632"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jez.10151"},{"key":"e_1_3_1_16_2","unstructured":"S. L. Reiner unpublished results."},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.19.3749"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01139-X"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni889"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082305"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/342559a0"},{"key":"e_1_3_1_22_2","unstructured":"C. Mao J. Rossant manuscript in preparation."},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082114899"},{"key":"e_1_3_1_24_2","unstructured":"We are grateful to N. Killeen K. Ryan and C. Gasink for critical insights; K. Sykes for exceptional assistance; and M. Bogumil W. DeMuth K. Foulds M. Gohil R. Jones M. Maldonado M. Mooney V. Prideaux J. Rathmell A. Russ D. Shedlock R. Vonderheide and L. Zenewicz for generous help. This work was supported by grants from the NIH (AI-042370 and GM-07229) and the generosity of Leonard and Madlyn Abramson."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1090148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T22:12:12Z","timestamp":1704838332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1090148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,7]]},"references-count":23,"journal-issue":{"issue":"5647","published-print":{"date-parts":[[2003,11,7]]}},"alternative-id":["10.1126\/science.1090148"],"URL":"https:\/\/doi.org\/10.1126\/science.1090148","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016163.200200","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016163.200359","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,7]]}}}