{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:57:14Z","timestamp":1791125834212,"version":"4.1.0"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5650","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,11,28]]},"abstract":"<jats:p>Paracaspase (MALT1), a member of an evolutionarily conserved superfamily of caspase-like proteins, has been shown to bind and colocalize with the protein Bcl10 in vitro and, because of this association, has been suggested to be involved in the CARMA1-Bcl10 pathway of antigen-induced nuclear factor \u03baB (NF-\u03baB) activation. We demonstrate that primary T and B lymphocytes from paracaspase-deficient mice are defective in antigen-receptor\u2013induced NF-\u03baB activation, cytokine production, and proliferation. Paracaspase acts downstream of Bcl10 to induce NF-\u03baB activation and is required for the normal development of B cells, indicating that paracaspase provides the missing link between Bcl10 and activation of the I\u03baB kinase complex.<\/jats:p>","DOI":"10.1126\/science.1090769","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T02:45:36Z","timestamp":1067309136000},"page":"1581-1584","source":"Crossref","is-referenced-by-count":345,"title":["Regulation of NF-\u03baB-Dependent Lymphocyte Activation and Development by Paracaspase"],"prefix":"10.1126","volume":"302","author":[{"given":"Astrid A.","family":"Ruefli-Brasse","sequence":"first","affiliation":[{"name":"Molecular Oncology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."},{"name":"Pathology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothy M.","family":"French","sequence":"additional","affiliation":[{"name":"Molecular Oncology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."},{"name":"Pathology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishva M.","family":"Dixit","sequence":"additional","affiliation":[{"name":"Molecular Oncology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."},{"name":"Pathology Department, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.225"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri799"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.621"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(03)00177-7"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00189-1"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00148-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00141-9"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00458-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00491-3"},{"key":"e_1_3_1_11_2","first-page":"961","volume":"6","year":"2000","unstructured":"A. G. Uren et al., Mol. Cell6, 961 (2000).","journal-title":"Mol. Cell"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200146"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/8767"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009984200"},{"key":"e_1_3_1_15_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_16_2","unstructured":"A. A. Ruefli-Brasse D. M. French V. M. Dixit unpublished observations."},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103824200"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.072071599"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni963"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00125480-200111000-00001"},{"key":"e_1_3_1_21_2","unstructured":"We thank F. Martin H. P. Gerber and Dixit lab members for reagents discussions and review of this manuscript; A. Uren for targeting constructs; H. Maecker for assistance with flow cytometry; and the transgenic lab facility for the generation and care of mice."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1090769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:31:40Z","timestamp":1704835900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1090769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,28]]},"references-count":20,"journal-issue":{"issue":"5650","published-print":{"date-parts":[[2003,11,28]]}},"alternative-id":["10.1126\/science.1090769"],"URL":"https:\/\/doi.org\/10.1126\/science.1090769","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1016245.202451","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1016245.200306","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,28]]}}}