{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:13:25Z","timestamp":1792145605364,"version":"4.4.0"},"reference-count":30,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5646","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2003,10,31]]},"abstract":"<jats:p>\n                    In conjunction with histone modifications, DNA methylation plays critical roles in gene silencing through chromatin remodeling. Changes in DNA methylation perturb neuronal function, and mutations in a methyl-CpG\u2013binding protein, MeCP2, are associated with Rett syndrome. We report that increased synthesis of brain-derived neurotrophic factor (BDNF) in neurons after depolarization correlates with a decrease in CpG methylation within the regulatory region of the\n                    <jats:italic>Bdnf<\/jats:italic>\n                    gene. Moreover, increased\n                    <jats:italic>Bdnf<\/jats:italic>\n                    transcription involves dissociation of the MeCP2\u2013histone deacetylase\u2013mSin3A repression complex from its promoter. Our findings suggest that DNA methylation\u2013related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity.\n                  <\/jats:p>","DOI":"10.1126\/science.1090842","type":"journal-article","created":{"date-parts":[[2003,10,30]],"date-time":"2003-10-30T20:25:22Z","timestamp":1067545522000},"page":"890-893","source":"Crossref","is-referenced-by-count":1243,"title":["DNA Methylation-Related Chromatin Remodeling in Activity-Dependent\n                    <i>Bdnf<\/i>\n                    Gene Regulation"],"prefix":"10.1126","volume":"302","author":[{"given":"Keri","family":"Martinowich","sequence":"first","affiliation":[{"name":"Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"Departments of Molecular and Medical Pharmacology and Psychiatry and Behavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"University of California, Los Angeles (UCLA) ACCESS program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"Department of Human Genetics, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Hattori","sequence":"additional","affiliation":[{"name":"Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"Departments of Molecular and Medical Pharmacology and Psychiatry and Behavioral Sciences, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"University of California, Los Angeles (UCLA) ACCESS program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA."},{"name":"Department of Human Genetics, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, 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thank G. Weinmaster and K. Martin for comments on the manuscript. Supported by predoctoral fellowships from the UCLA Mental Retardation Research Center (K.M.) and Jonsson Cancer Center Foundation (JCCF) (S.D.F.) and by grants from NIH NS44405 March of Dimes and JCCF (G.F.) and from the Arnold and Mabel Beckman Foundation (Y.E.S.)."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1090842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T22:22:48Z","timestamp":1704838968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1090842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,31]]},"references-count":30,"journal-issue":{"issue":"5646","published-print":{"date-parts":[[2003,10,31]]}},"alternative-id":["10.1126\/science.1090842"],"URL":"https:\/\/doi.org\/10.1126\/science.1090842","relation":{},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,10,31]]}}}