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However, the genes associated with inherited susceptibility to late-onset neurodegenerative diseases, schizophrenia, and bipolar disorder appear to have smaller effects and are likely to interact with each other (and with nongenetic factors) to modulate susceptibility and\/or disease phenotype. Several strategies have recently been applied to address this complexity, leading to the identification of a number of candidate susceptibility loci\/genes.<\/jats:p>","DOI":"10.1126\/science.1092132","type":"journal-article","created":{"date-parts":[[2003,10,31]],"date-time":"2003-10-31T01:25:22Z","timestamp":1067563522000},"page":"822-826","source":"Crossref","is-referenced-by-count":117,"title":["The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?"],"prefix":"10.1126","volume":"302","author":[{"given":"James L.","family":"Kennedy","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Medicine, Centre for Addiction and Mental Health, Centre for Research in Neurodegenerative Diseases, University of Toronto; and Department of Medicine (Division of Neurology), The University Health Network, Toronto, Ontario M5S 3H9, Canada."},{"name":"Departments of Medicine, Neurology, and Genetics &amp; Genomics, Boston University School of Medicine; and Departments of Epidemiology and Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA."},{"name":"Department of Psychiatry, University of Iowa; and Departments of Psychiatry and Neurology, University of New Mexico, The MIND Institute, Albuquerque, NM 87106, USA."},{"name":"Gertrude H. 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