{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:43:33Z","timestamp":1791164613536,"version":"4.1.0"},"reference-count":27,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5670","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,4,23]]},"abstract":"<jats:p>\n                    Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric \u03b1 chains of the CD8 molecule (CD8\u03b1\u03b1) are transiently induced on a selected subset of CD8\u03b1\u03b2\n                    <jats:sup>+<\/jats:sup>\n                    T cells upon antigenic stimulation. These CD8\u03b1\u03b1 molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8\u03b1\u03b1.\n                  <\/jats:p>","DOI":"10.1126\/science.1092316","type":"journal-article","created":{"date-parts":[[2004,4,22]],"date-time":"2004-04-22T16:23:24Z","timestamp":1082651004000},"page":"590-593","source":"Crossref","is-referenced-by-count":146,"title":["CD8\u03b1\u03b1-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors"],"prefix":"10.1126","volume":"304","author":[{"given":"Loui T.","family":"Madakamutil","sequence":"first","affiliation":[{"name":"La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA."},{"name":"Howard Hughes Medical Institute and Skirball Institute of Biomedical Science, New York University School of Medicine, New York, NY 10016, USA."},{"name":"Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, 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