{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:36:14Z","timestamp":1791048974652,"version":"4.1.0"},"reference-count":32,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5679","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,6,25]]},"abstract":"<jats:p>We examined dendritic protein synthesis after a prolonged blockade of action potentials alone and after a blockade of both action potentials and miniature excitatory synaptic events (minis). Relative to controls, dendrites exposed to a prolonged blockade of action potentials showed diminished protein synthesis. Dendrites in which both action potentials and minis were blocked showed enhanced protein synthesis, suggesting that minis inhibit dendritic translation. When minis were acutely blocked or stimulated, an immediate increase or decrease, respectively, in dendritic translation was observed. Taken together, these results reveal a role for miniature synaptic events in the acute regulation of dendritic protein synthesis in neurons.<\/jats:p>","DOI":"10.1126\/science.1096202","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T16:08:20Z","timestamp":1088093300000},"page":"1979-1983","source":"Crossref","is-referenced-by-count":231,"title":["Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events"],"prefix":"10.1126","volume":"304","author":[{"given":"Michael A.","family":"Sutton","sequence":"first","affiliation":[{"name":"Division of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Wall","sequence":"additional","affiliation":[{"name":"Division of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish N.","family":"Aakalu","sequence":"additional","affiliation":[{"name":"Division of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Schuman","sequence":"additional","affiliation":[{"name":"Division of Biology, Howard Hughes Medical Institute (HHMI), California Institute of Technology, Pasadena, CA 91125, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00295-1"},{"key":"e_1_3_1_3_2","unstructured":"Neurons were imaged in HEPES-buffered saline. Under these conditions extracellular glutamate levels were <100 nM and did not increase over the course of the experiment ( 31 )."},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1113\/jphysiol.1952.sp004735","volume":"117","year":"1952","unstructured":"P. Fatt, B. Katz, J. Physiol.117, 109 (1952).","journal-title":"J. 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Patrick C. Jiang and C.-Y. Tai for critically reading the manuscript H. Weld for making beautiful cultured hippocampal neurons and all members of the Schuman lab. Supported by the Damon Runyon Walter Winchell Fund (M.A.S.) and the NIH (E.M.S.). E.M.S. is an associate investigator of HHMI."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1096202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T23:25:51Z","timestamp":1704842751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1096202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,25]]},"references-count":32,"journal-issue":{"issue":"5679","published-print":{"date-parts":[[2004,6,25]]}},"alternative-id":["10.1126\/science.1096202"],"URL":"https:\/\/doi.org\/10.1126\/science.1096202","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1019776.224442","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6,25]]}}}