{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:21:19Z","timestamp":1791328879066,"version":"4.3.1"},"reference-count":31,"publisher":"American Association for the Advancement of Science (AAAS)","issue":"5684","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Science"],"published-print":{"date-parts":[[2004,7,30]]},"abstract":"<jats:p>\n                    We transformed the native tobacco,\n                    <jats:italic>Nicotiana attenuata<\/jats:italic>\n                    , to silence its lipoxygenase, hydroperoxide lyase, and allene oxide synthase genes in order to inhibit oxylipin signaling, known to mediate the plant's direct and indirect defenses. When planted into native habitats, lipoxygenase-deficient plants were more vulnerable to\n                    <jats:italic>N. attenuata<\/jats:italic>\n                    's adapted herbivores but also attracted novel herbivore species, which fed and reproduced successfully. In addition to highlighting the value of genetically silencing plants to study ecological interactions in nature, these results show that lipoxygenase-dependent signaling determines host selection for opportunistic herbivores and that induced defenses influence herbivore community composition.\n                  <\/jats:p>","DOI":"10.1126\/science.1096931","type":"journal-article","created":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T20:31:08Z","timestamp":1088713868000},"page":"665-668","source":"Crossref","is-referenced-by-count":451,"title":["Silencing the Jasmonate Cascade: Induced Plant Defenses and Insect Populations"],"prefix":"10.1126","volume":"305","author":[{"given":"Andre\u0301","family":"Kessler","sequence":"first","affiliation":[{"name":"Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Hans-Kno\u0308ll-Strasse 8, Jena 07745, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayko","family":"Halitschke","sequence":"additional","affiliation":[{"name":"Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Hans-Kno\u0308ll-Strasse 8, Jena 07745, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Molecular Ecology, Max-Planck-Institute for Chemical Ecology, Hans-Kno\u0308ll-Strasse 8, Jena 07745, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6327(1996)32:1<3::AID-ARCH2>3.0.CO;2-1"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/31219"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1570-7458.2000.00736.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2311.2001.00324.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5511.2141"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.250.4985.1251"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","unstructured":"R. Karban I. T. Baldwin Induced Responses to Herbivory (Univ. of Chicago Press Chicago IL 1997).","DOI":"10.7208\/chicago\/9780226424972.001.0001"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1060701"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.2307\/176627"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-313X.2004.02076.x"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1104\/pp.125.2.711"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1360-1385(02)02290-2"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.48.1.355"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1996.0242"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.3.1146"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305096101"},{"key":"e_1_3_1_18_2","unstructured":"Materials and methods are available as supporting material on Science Online."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2003.01921.x"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.017954"},{"key":"e_1_3_1_21_2","unstructured":"R. Halitschke M. Keinanen J. Ziegler I. T. Baldwin Plant J. in press."},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00983793"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313x.1998.00324.x"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-1978(01)00049-7"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-313X.2002.01328.x"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.190264497"},{"key":"e_1_3_1_27_2","unstructured":"As plants began to elongate and produce flowers they were examined daily; all flowers were removed before opening and anthesis to meet the performance standards determined in the Code of Federal Regulations [7CFR340.3(c)] for the Introduction of Organisms Altered or Produced through Genetic Engineering. Consequently direct fitness measures were unattainable in these experiments."},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20020701)25:10\/11<677::AID-JSSC677>3.0.CO;2-5"},{"key":"e_1_3_1_29_2","unstructured":"Probably belonging to the species E. fabae (Harris 1841) which is widely known as a pest on alfalfa in the United States."},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01003"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.2307\/1941237"},{"key":"e_1_3_1_32_2","unstructured":"Supported by the Max-Planck-Gesellschaft and Deutsche Forschungsgemeinschaft (BA-2132\/1-1). We thank E. Wheeler E. Pichersky D. Heckel J. Gershenzon M. Heil and H. Vogel for helpful comments; R. Baumann P. Freytag and H. Nickel for assistance with species determination; and Brigham Young University for use of Lytle Preserve as a field station; L. Rausing for helping us promote the discussion of the scientific value of transformed plants; and J. White and the Animal and Plant Health Inspection Service personnel for facilitating their safe use in nature."}],"container-title":["Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.science.org\/doi\/pdf\/10.1126\/science.1096931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T20:53:27Z","timestamp":1704833607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.science.org\/doi\/10.1126\/science.1096931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,30]]},"references-count":31,"journal-issue":{"issue":"5684","published-print":{"date-parts":[[2004,7,30]]}},"alternative-id":["10.1126\/science.1096931"],"URL":"https:\/\/doi.org\/10.1126\/science.1096931","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1023768.283713","asserted-by":"object"}]},"ISSN":["0036-8075","1095-9203"],"issn-type":[{"value":"0036-8075","type":"print"},{"value":"1095-9203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,30]]}}}